TY - JOUR
T1 - Predictors of poor outcome despite recanalization
T2 - A multiple regression analysis of the NASA registry
AU - Linfante, Italo
AU - Starosciak, Amy K.
AU - Walker, Gail R.
AU - Dabus, Guilherme
AU - Castonguay, Alicia C.
AU - Gupta, Rishi
AU - Sun, Chung Huan J.
AU - Martin, Coleman
AU - Holloway, William E.
AU - Mueller-Kronast, Nils
AU - English, Joey D.
AU - Malisch, Tim W.
AU - Marden, Franklin A.
AU - Bozorgchami, Hormozd
AU - Xavier, Andrew
AU - Rai, Ansaar T.
AU - Froehler, Michael T.
AU - Badruddin, Aamir
AU - Nguyen, Thanh N.
AU - Taqi, M. Asif
AU - Abraham, Michael G.
AU - Janardhan, Vallabh
AU - Shaltoni, Hashem
AU - Novakovic, Roberta
AU - Yoo, Albert J.
AU - Abou-Chebl, Alex
AU - Chen, Peng R.
AU - Britz, Gavin W.
AU - Kaushal, Ritesh
AU - Nanda, Ashish
AU - Issa, Mohammad A.
AU - Nogueira, Raul G.
AU - Zaidat, Osama O.
PY - 2016/3
Y1 - 2016/3
N2 - Background Mechanical thrombectomy with stentretrievers results in higher recanalization rates compared with previous devices. Despite successful recanalization rates (Thrombolysis in Cerebral Infarction (TICI) score ?2b) of 70-83%, good outcomes by 90-day modified Rankin Scale (MRS) score ?2 are achieved in only 40-55% of patients. We evaluated predictors of poor outcomes (MRS >2) despite successful recanalization (TICI ?2b) in the North American Solitaire Stent Retriever Acute Stroke (NASA) registry. Methods Logistic regression was used to evaluate baseline characteristics and recanalization outcomes for association with 90-day MRS score of 0-2 (good outcome) vs 3-6 ( poor outcome). Univariate tests were carried out for all factors. A multivariable model was developed based on backwards selection from the factors with at least marginal significance (p?0.10) on univariate analysis with the retention criterion set at p?0.05. The model was refit to minimize the number of cases excluded because of missing covariate values; the c-statistic was a measure of predictive power. Results Of 354 patients, 256 (72.3%) were recanalized successfully. Based on 234 recanalized patients evaluated for 90-day MRS score, 116 (49.6%) had poor outcomes. Univariate analysis identified an increased risk of poor outcome for age ?80 years, occlusion site of internal carotid artery (ICA)/basilar artery, National Institute of Health Stroke Scale (NIHSS) score ?18, history of diabetes mellitus, TICI 2b, use of rescue therapy, not using a balloon-guided catheter or intravenous tissue plasminogen activator (IV t-PA), and >30 min to recanalization (p?0.05). In multivariable analysis, age ?80 years, occlusion site ICA/basilar, initial NIHSS score ?18, diabetes, absence of IV t-PA, ?3 passes, and use of rescue therapy were significant independent predictors of poor 90-day outcome in a model with good predictive power (c-index=0.80). Conclusions Age, occlusion site, high NIHSS, diabetes, no IV t-PA, ?3 passes, and use of rescue therapy are associated with poor 90-day outcome despite successful recanalization.
AB - Background Mechanical thrombectomy with stentretrievers results in higher recanalization rates compared with previous devices. Despite successful recanalization rates (Thrombolysis in Cerebral Infarction (TICI) score ?2b) of 70-83%, good outcomes by 90-day modified Rankin Scale (MRS) score ?2 are achieved in only 40-55% of patients. We evaluated predictors of poor outcomes (MRS >2) despite successful recanalization (TICI ?2b) in the North American Solitaire Stent Retriever Acute Stroke (NASA) registry. Methods Logistic regression was used to evaluate baseline characteristics and recanalization outcomes for association with 90-day MRS score of 0-2 (good outcome) vs 3-6 ( poor outcome). Univariate tests were carried out for all factors. A multivariable model was developed based on backwards selection from the factors with at least marginal significance (p?0.10) on univariate analysis with the retention criterion set at p?0.05. The model was refit to minimize the number of cases excluded because of missing covariate values; the c-statistic was a measure of predictive power. Results Of 354 patients, 256 (72.3%) were recanalized successfully. Based on 234 recanalized patients evaluated for 90-day MRS score, 116 (49.6%) had poor outcomes. Univariate analysis identified an increased risk of poor outcome for age ?80 years, occlusion site of internal carotid artery (ICA)/basilar artery, National Institute of Health Stroke Scale (NIHSS) score ?18, history of diabetes mellitus, TICI 2b, use of rescue therapy, not using a balloon-guided catheter or intravenous tissue plasminogen activator (IV t-PA), and >30 min to recanalization (p?0.05). In multivariable analysis, age ?80 years, occlusion site ICA/basilar, initial NIHSS score ?18, diabetes, absence of IV t-PA, ?3 passes, and use of rescue therapy were significant independent predictors of poor 90-day outcome in a model with good predictive power (c-index=0.80). Conclusions Age, occlusion site, high NIHSS, diabetes, no IV t-PA, ?3 passes, and use of rescue therapy are associated with poor 90-day outcome despite successful recanalization.
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U2 - 10.1136/neurintsurg-2014-011525
DO - 10.1136/neurintsurg-2014-011525
M3 - Article
C2 - 25564538
AN - SCOPUS:84958659536
SN - 1759-8478
VL - 8
SP - 224
EP - 229
JO - Journal of neurointerventional surgery
JF - Journal of neurointerventional surgery
IS - 3
ER -