Postnatal development of T lymphocytes in a novel X-linked immunodeficiency disease

Frank C. Schmalstieg, Daniel P. Wirt, Linda T. Adkins, Edward G. Brooks, Susan D. Stansberry, Leonard E. Swischuk, Armond S. Goldman

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


We previously reported an X-linked combined immunode-ficiency disease (CID) characterized by immune deficiencies and complicating infections that were more moderate than those found in severe CID (SCID). Since other unstudied males in the family died in infancy, we questioned whether this T cell defect was more profound in early life. Subsequently, the development of blood T cells in an affected new-born male was examined. T cells were virtually undetectable at 48 hr. Over the next several months, CD4+ T cells (principally CD45RO+) rose to levels similar to those found in older affected males, but CD8+ T cells developed more slowly and never attained levels found in other affected males. Thus, this disease in early life mimics SCID and may pose a higher risk of fatal infections to affected individuals during that period. Finally, we speculate that the genetic defect may disrupt intrathymic development or selection of T cells.

Original languageEnglish (US)
Pages (from-to)71-77
Number of pages7
JournalClinical Immunology and Immunopathology
Issue number1
StatePublished - Jul 1992
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pathology and Forensic Medicine
  • Immunology


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