Positive‐outcome Bias: Comparison of Emergency Medicine and General Medicine Literatures

Ronald Moscati, Dietrich Jehle, David Ellis, Albert Fiorello, Michael Landi

Research output: Contribution to journalArticlepeer-review

Abstract

Objective:The existence of positive‐outcome bias in the medical literature is well established. Positive‐outcome bias in two emergency medicine journals was compared with that found in two general medicine journals. Methods:Published original contributions from Annals of Emergency Medicine, American Journal of Emergency Medicine, JAMA, and New England Journal of Medicinewere reviewed. Articles were categorized as demonstrating a positive or negative outcome or showing no difference using new criteria. Descriptive articles were excluded. Results:Of 700 articles reviewed, 177 emergency medicine and 211 general medicine articles met the study criteria. The emergency medicine journals had 142 articles (80%) with positive outcomes, 27 (15%) with negative outcomes, and 8 (5%) with no difference. The general medicine journals had 169 articles (80%) with positive outcomes, 33 (16%) with negative outcomes, and 9 (4%) with no difference. There was no significant difference between journal groups (chi‐square; p = 0.99). The power of the study was 0.80 to detect a difference of 15% between groups with alpha set at 0.05. Conclusions:There was no significant difference in the proportions of positive‐outcome studies published in this sample of the emergency medicine literature compared with the general medicine literature. The potential impact of positive‐outcome bias and methods of dealing with the problem are reviewed.

Original languageEnglish (US)
Pages (from-to)267-271
Number of pages5
JournalAcademic Emergency Medicine
Volume1
Issue number3
DOIs
StatePublished - May 1994
Externally publishedYes

Keywords

  • clinical trials
  • emergency medicine
  • laboratory investigation
  • medical literature
  • positive outcome bias

ASJC Scopus subject areas

  • Emergency Medicine

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