Polymorphism of MTHFR and MTRR in Czech patients with cardiovascular diseases and stroke

R. Matalon; S. Rady; K. Szucs; P. Matalon; J. Hyánek; P. Šebesta; J. Matoušková; N. Vondráčková; H. Pejznochová; L. Dubská; H. Přindisová; J. Dvořáková; M. Loučka; V. Martiniková; M. Šlancová

Polymorphism of MTHFR and MTRR in Czech patients with cardiovascular diseases and stroke

R. Matalon, S. Rady, K. Szucs, P. Matalon, J. Hyánek, P. Šebesta, J. Matoušková, N. Vondráčková, H. Pejznochová, L. Dubská, H. Přindisová, J. Dvořáková, M. Loučka, V. Martiniková, M. Šlancová

Pediatrics

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Blood from 27 Czech patients with cardiovascular disease and stroke, who also had hyperhomocysteinemia, was analyzed for methylene tetrahydrofolate reductase (MTHFR) polymorphism. These patients had significantly higher incidence of MTHFR 677 C > T polymorphism compared to controls (p < 0.001). The incidence the MTHFR 1298 A > C and methionine synthase reductase (MTRR) 66 A > G polymorphism was not significantly different. The hyperhomocysteinemia in 70% of these patients was reversible by folate supplementation.

Original language	English (US)
Pages (from-to)	418-420
Number of pages	3
Journal	Cesko-Slovenska Pediatrie
Volume	58
Issue number	7
State	Published - 2003

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

Cite this

@article{8dd8c7574c46407baf30d1f0aa6471f7,

title = "Polymorphism of MTHFR and MTRR in Czech patients with cardiovascular diseases and stroke",

abstract = "Blood from 27 Czech patients with cardiovascular disease and stroke, who also had hyperhomocysteinemia, was analyzed for methylene tetrahydrofolate reductase (MTHFR) polymorphism. These patients had significantly higher incidence of MTHFR 677 C > T polymorphism compared to controls (p < 0.001). The incidence the MTHFR 1298 A > C and methionine synthase reductase (MTRR) 66 A > G polymorphism was not significantly different. The hyperhomocysteinemia in 70% of these patients was reversible by folate supplementation.",

author = "R. Matalon and S. Rady and K. Szucs and P. Matalon and J. Hy{\'a}nek and P. {\v S}ebesta and J. Matou{\v s}kov{\'a} and N. Vondr{\'a}{\v c}kov{\'a} and H. Pejznochov{\'a} and L. Dubsk{\'a} and H. P{\v r}indisov{\'a} and J. Dvo{\v r}{\'a}kov{\'a} and M. Lou{\v c}ka and V. Martinikov{\'a} and M. {\v S}lancov{\'a}",

year = "2003",

language = "English (US)",

volume = "58",

pages = "418--420",

journal = "Cesko-Slovenska Pediatrie",

issn = "0069-2328",

publisher = "Czech Medical Association J.E. Purkyne",

number = "7",

}

TY - JOUR

T1 - Polymorphism of MTHFR and MTRR in Czech patients with cardiovascular diseases and stroke

AU - Matalon, R.

AU - Rady, S.

AU - Szucs, K.

AU - Matalon, P.

AU - Hyánek, J.

AU - Šebesta, P.

AU - Matoušková, J.

AU - Vondráčková, N.

AU - Pejznochová, H.

AU - Dubská, L.

AU - Přindisová, H.

AU - Dvořáková, J.

AU - Loučka, M.

AU - Martiniková, V.

AU - Šlancová, M.

PY - 2003

Y1 - 2003

N2 - Blood from 27 Czech patients with cardiovascular disease and stroke, who also had hyperhomocysteinemia, was analyzed for methylene tetrahydrofolate reductase (MTHFR) polymorphism. These patients had significantly higher incidence of MTHFR 677 C > T polymorphism compared to controls (p < 0.001). The incidence the MTHFR 1298 A > C and methionine synthase reductase (MTRR) 66 A > G polymorphism was not significantly different. The hyperhomocysteinemia in 70% of these patients was reversible by folate supplementation.

AB - Blood from 27 Czech patients with cardiovascular disease and stroke, who also had hyperhomocysteinemia, was analyzed for methylene tetrahydrofolate reductase (MTHFR) polymorphism. These patients had significantly higher incidence of MTHFR 677 C > T polymorphism compared to controls (p < 0.001). The incidence the MTHFR 1298 A > C and methionine synthase reductase (MTRR) 66 A > G polymorphism was not significantly different. The hyperhomocysteinemia in 70% of these patients was reversible by folate supplementation.

UR - http://www.scopus.com/inward/record.url?scp=0042023524&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0042023524&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0042023524

SN - 0069-2328

VL - 58

SP - 418

EP - 420

JO - Cesko-Slovenska Pediatrie

JF - Cesko-Slovenska Pediatrie

IS - 7

ER -

Polymorphism of MTHFR and MTRR in Czech patients with cardiovascular diseases and stroke

Abstract

ASJC Scopus subject areas

Other files and links

Fingerprint

Cite this