Polyhydroxy-N-alkyl-2-pyrrolidinones as a new class of glycolipid analogues with immune modulation potential

Srinivasa Reddy Bonam, Jaggaiah Naidu Gorantla, Arun Kumar Thangarasu, Ravi Shankar Lankalapalli, Halmuthur Mahabalarao Sampath Kumar

Research output: Contribution to journalArticlepeer-review


A focused library of novel N-alkyl-2-pyrrolidinone derivatives 3a-e was synthesized from D-galactose employing a multistep chiron approach. These novel glycolipid analogues exhibited lipopolysaccharide-mediated splenocyte proliferation with no apparent toxicity against murine splenocytes. Various immunological assays on dendritic cells, macrophages, and human peripheral blood mononuclear cells have ascertained the immunostimulatory activity of these new glycolipid analogues.

Original languageEnglish (US)
Pages (from-to)30-43
Number of pages14
JournalJournal of Carbohydrate Chemistry
Issue number1
StatePublished - Jan 2 2018
Externally publishedYes


  • Dendritic cells
  • N-alkyl-2-pyrrolidinone
  • cytokines
  • hPBMCs
  • macrophages

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry


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