Platelet receptor-mediated mechanosensing and thrombosis

Lining A. Ju, Yunfeng Chen, Zhenhai Li, Cheng Zhu

Research output: Chapter in Book/Report/Conference proceedingChapter


One example demonstrating the significance of studying cell mechanosensing is the platelet-mediated blood clot formation (thrombosis) under shear that causes heart attack and stroke-the No. 1 killer worldwide. As an emerging concept, shear forces generated by the hemodynamic flow disturbances have been shown to promote rapid platelet aggregation, which is usually seen in a narrowing vessel due to a growing thrombus, an atherosclerotic plaque, or an interventional device. Notably, this biomechanical mechanism not only challenges the classic agonist-dependent (biochemical) thrombosis model but also demonstrates resistance to the existing antithrombotic agents. Furthermore, recent studies indicate that this biomechanical platelet aggregation requires the interaction of platelet receptor glycoprotein Ibα (GPIbα) with von Willebrand factor (VWF) in plasma. This chapter will summarize the latest understandings on the platelet mechanosensing principles that center the VWF-GPIbα axis. Clinically, this platelet mechanosensing pathway represents a novel therapeutic target for an anti-thrombotic purpose.

Original languageEnglish (US)
Title of host publicationMechanobiology in Health and Disease
Number of pages20
ISBN (Electronic)9780128129524
ISBN (Print)9780128129531
StatePublished - Jan 1 2018
Externally publishedYes


  • Biomembrane force probe
  • Flow disturbance
  • Force spectroscopy
  • GPIb
  • Leucine-rich repeat
  • Platelet
  • Shear
  • Single molecule
  • Thrombosis
  • Von Willebrand factor

ASJC Scopus subject areas

  • General Engineering
  • General Biochemistry, Genetics and Molecular Biology


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