Abstract
We tested the hypotheses that the levels of insulin-like growth factor I (IGF-I) reflect the degree of control during the treatment of patients with congenital adrenal hyperplasia (CAH), and that suppressed IGF-I levels during puberty contribute to decreased adult height. We measured serial IGF-I levels in 26 CAH patients followed over 6 months to 5 years. The control of CAH was variable, with several cases of overtreatment in infancy, and frequent undertreatment in childhood and adolescence. IGF-I levels were quite variable and inconsistent with the control of CAH. Our results suggest that IGF-I levels are not helpful in monitoring CAH patients; IGF-I does not seem to play a role in the growth failure during CAH therapy.
Original language | English (US) |
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Pages (from-to) | 23-26 |
Number of pages | 4 |
Journal | Hormone Research in Paediatrics |
Volume | 34 |
Issue number | 1 |
DOIs | |
State | Published - 1990 |
Keywords
- Congenital adrenal hyperplasia
- Growth
- Insulin-like growth factor I
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Endocrinology, Diabetes and Metabolism
- Endocrinology