Placental control of drug delivery

Sanaalarab Al-Enazy; Shariq Ali; Norah Albekairi; Marwa El-Tawil; Erik Rytting

doi:10.1016/j.addr.2016.08.002

Placental control of drug delivery

Sanaalarab Al-Enazy, Shariq Ali, Norah Albekairi, Marwa El-Tawil, Erik Rytting

Obstetrics & Gynecology

Research output: Contribution to journal › Review article › peer-review

29 Scopus citations

Abstract

The placenta serves as the interface between the maternal and fetal circulations and regulates the transfer of oxygen, nutrients, and waste products. When exogenous substances are present in the maternal bloodstream—whether from environmental contact, occupational exposure, medication, or drug abuse—the extent to which this exposure affects the fetus is determined by transport and biotransformation processes in the placental barrier. Advances in drug delivery strategies are expected to improve the treatment of maternal and fetal diseases encountered during pregnancy.

Original language	English (US)
Pages (from-to)	63-72
Number of pages	10
Journal	Advanced Drug Delivery Reviews
Volume	116
DOIs	https://doi.org/10.1016/j.addr.2016.08.002
State	Published - Jul 1 2017

Keywords

Biotransformation
Placenta
Pregnancy
Transporters

ASJC Scopus subject areas

Pharmaceutical Science

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10.1016/j.addr.2016.08.002

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title = "Placental control of drug delivery",

abstract = "The placenta serves as the interface between the maternal and fetal circulations and regulates the transfer of oxygen, nutrients, and waste products. When exogenous substances are present in the maternal bloodstream—whether from environmental contact, occupational exposure, medication, or drug abuse—the extent to which this exposure affects the fetus is determined by transport and biotransformation processes in the placental barrier. Advances in drug delivery strategies are expected to improve the treatment of maternal and fetal diseases encountered during pregnancy.",

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author = "Sanaalarab Al-Enazy and Shariq Ali and Norah Albekairi and Marwa El-Tawil and Erik Rytting",

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T1 - Placental control of drug delivery

AU - Al-Enazy, Sanaalarab

AU - Ali, Shariq

AU - Albekairi, Norah

AU - El-Tawil, Marwa

AU - Rytting, Erik

PY - 2017/7/1

Y1 - 2017/7/1

N2 - The placenta serves as the interface between the maternal and fetal circulations and regulates the transfer of oxygen, nutrients, and waste products. When exogenous substances are present in the maternal bloodstream—whether from environmental contact, occupational exposure, medication, or drug abuse—the extent to which this exposure affects the fetus is determined by transport and biotransformation processes in the placental barrier. Advances in drug delivery strategies are expected to improve the treatment of maternal and fetal diseases encountered during pregnancy.

AB - The placenta serves as the interface between the maternal and fetal circulations and regulates the transfer of oxygen, nutrients, and waste products. When exogenous substances are present in the maternal bloodstream—whether from environmental contact, occupational exposure, medication, or drug abuse—the extent to which this exposure affects the fetus is determined by transport and biotransformation processes in the placental barrier. Advances in drug delivery strategies are expected to improve the treatment of maternal and fetal diseases encountered during pregnancy.

KW - Biotransformation

KW - Placenta

KW - Pregnancy

KW - Transporters

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UR - http://www.scopus.com/inward/citedby.url?scp=84994608138&partnerID=8YFLogxK

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DO - 10.1016/j.addr.2016.08.002

M3 - Review article

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AN - SCOPUS:84994608138

SN - 0169-409X

VL - 116

SP - 63

EP - 72

JO - Advanced Drug Delivery Reviews

JF - Advanced Drug Delivery Reviews

ER -

Placental control of drug delivery

Abstract

Keywords

ASJC Scopus subject areas

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