Pigment gallstone composition in cirrhotic and noncirrhotic subjects

Bruce W. Trotman; Thomas A. Morris; Heide M. Cheney; J. Donald Ostrow; Harry M. Sanchez; Roger D. Soloway; Harold O. Conn

doi:10.1007/BF01072458

Pigment gallstone composition in cirrhotic and noncirrhotic subjects

Bruce W. Trotman, Thomas A. Morris, Heide M. Cheney, J. Donald Ostrow, Harry M. Sanchez, Roger D. Soloway, Harold O. Conn

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20 Scopus citations

Abstract

The composition of pigment gallstones from patients with and without cirrhosis was compared. Carbonate-containing pigment stones were distinguished from noncarbonate stones by infrared spectroscopy. Calcium was the major cation of each stone group. The major anion in noncarbonate pigment stones was bilirubinate or phosphate, but was carbonate in carbonate stones. The composition of pigment stones from cirrhotic and noncirrhotic patients was similar except that significantly less carbonate was present in carbonate stones, and less pigment (bilirubinate) was present in noncarbonate stones from noncirrhotics. These data suggest that irrespective of the presence of cirrhosis, the formation of noncarbonate pigment stones involves the selective precipitation of calcium bilirubinate and phosphate, whereas carbonate stone formation involves the selective precipitation of calcium carbonate.

Original language	English (US)
Pages (from-to)	872-876
Number of pages	5
Journal	The American Journal of Digestive Diseases
Volume	23
Issue number	10
DOIs	https://doi.org/10.1007/BF01072458
State	Published - Oct 1978
Externally published	Yes

ASJC Scopus subject areas

Gastroenterology

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title = "Pigment gallstone composition in cirrhotic and noncirrhotic subjects",

abstract = "The composition of pigment gallstones from patients with and without cirrhosis was compared. Carbonate-containing pigment stones were distinguished from noncarbonate stones by infrared spectroscopy. Calcium was the major cation of each stone group. The major anion in noncarbonate pigment stones was bilirubinate or phosphate, but was carbonate in carbonate stones. The composition of pigment stones from cirrhotic and noncirrhotic patients was similar except that significantly less carbonate was present in carbonate stones, and less pigment (bilirubinate) was present in noncarbonate stones from noncirrhotics. These data suggest that irrespective of the presence of cirrhosis, the formation of noncarbonate pigment stones involves the selective precipitation of calcium bilirubinate and phosphate, whereas carbonate stone formation involves the selective precipitation of calcium carbonate.",

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TY - JOUR

T1 - Pigment gallstone composition in cirrhotic and noncirrhotic subjects

AU - Trotman, Bruce W.

AU - Morris, Thomas A.

AU - Cheney, Heide M.

AU - Ostrow, J. Donald

AU - Sanchez, Harry M.

AU - Soloway, Roger D.

AU - Conn, Harold O.

PY - 1978/10

Y1 - 1978/10

N2 - The composition of pigment gallstones from patients with and without cirrhosis was compared. Carbonate-containing pigment stones were distinguished from noncarbonate stones by infrared spectroscopy. Calcium was the major cation of each stone group. The major anion in noncarbonate pigment stones was bilirubinate or phosphate, but was carbonate in carbonate stones. The composition of pigment stones from cirrhotic and noncirrhotic patients was similar except that significantly less carbonate was present in carbonate stones, and less pigment (bilirubinate) was present in noncarbonate stones from noncirrhotics. These data suggest that irrespective of the presence of cirrhosis, the formation of noncarbonate pigment stones involves the selective precipitation of calcium bilirubinate and phosphate, whereas carbonate stone formation involves the selective precipitation of calcium carbonate.

AB - The composition of pigment gallstones from patients with and without cirrhosis was compared. Carbonate-containing pigment stones were distinguished from noncarbonate stones by infrared spectroscopy. Calcium was the major cation of each stone group. The major anion in noncarbonate pigment stones was bilirubinate or phosphate, but was carbonate in carbonate stones. The composition of pigment stones from cirrhotic and noncirrhotic patients was similar except that significantly less carbonate was present in carbonate stones, and less pigment (bilirubinate) was present in noncarbonate stones from noncirrhotics. These data suggest that irrespective of the presence of cirrhosis, the formation of noncarbonate pigment stones involves the selective precipitation of calcium bilirubinate and phosphate, whereas carbonate stone formation involves the selective precipitation of calcium carbonate.

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Pigment gallstone composition in cirrhotic and noncirrhotic subjects

Abstract

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