Abstract
Phenytoin produces significant liver glutathione depletion in vivo in mice. Pretreatment with inducers and inhibitors of drug metabolism show enhancement of phenytoin-induced glutathione depletion following phenobarbital and 3-methylcholanthrene pretreatment, inhibition of glutathione depletion following piperonyl butoxide, cobaltous chloride and alpha-naphthylisothiocyanate pretreatment (all drug metabolism inhibitors), and prevention of glutathione depletion following butylated hydroxytoluene pretreatment (both inducers of epoxide hydrolase). These data suggest that phenytoin-induced liver glutathione depletion may occur via a reactive metabolite and that this reactive metabolite possibly may be an epoxide.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 5-7 |
| Number of pages | 3 |
| Journal | Veterinary and Human Toxicology |
| Volume | 23 |
| Issue number | Suppl. 1 |
| State | Published - 1981 |
| Externally published | Yes |
ASJC Scopus subject areas
- Toxicology
- General Veterinary
- Health, Toxicology and Mutagenesis