Phenytoin liver glutathione depletion. A possible mechanism of liver injury

W. R. Snodgrass, S. Whitfield

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Phenytoin produces significant liver glutathione depletion in vivo in mice. Pretreatment with inducers and inhibitors of drug metabolism show enhancement of phenytoin-induced glutathione depletion following phenobarbital and 3-methylcholanthrene pretreatment, inhibition of glutathione depletion following piperonyl butoxide, cobaltous chloride and alpha-naphthylisothiocyanate pretreatment (all drug metabolism inhibitors), and prevention of glutathione depletion following butylated hydroxytoluene pretreatment (both inducers of epoxide hydrolase). These data suggest that phenytoin-induced liver glutathione depletion may occur via a reactive metabolite and that this reactive metabolite possibly may be an epoxide.

Original languageEnglish (US)
Pages (from-to)5-7
Number of pages3
JournalVeterinary and Human Toxicology
Issue numberSuppl. 1
StatePublished - 1981
Externally publishedYes

ASJC Scopus subject areas

  • Toxicology
  • General Veterinary
  • Health, Toxicology and Mutagenesis


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