Phencyclidine and marijuana exposure in utero

John O. Ogunbileje; Paul E. Young; Anthony O. Okorodudu

doi:10.1016/B978-0-12-815846-3.00100-9

Phencyclidine and marijuana exposure in utero

John O. Ogunbileje, Paul E. Young, Anthony O. Okorodudu

Pathology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

The rate of illicit drug abuse during pregnancy has been on the increase in recent years. Intrauterine exposure to illicit drugs may be teratogenic to the fetus. We present a case of a pregnant woman with a history of marijuana and phencyclidine (PCP) abuse. After delivery, PCP was detected in her baby’s urine using both the screening immunoassay and confirmatory liquid chromatography-tandem mass spectrometry techniques. Meconium sample was sent to a reference laboratory where it was analyzed by immunoassay with positive test results for PCP and tetrahydrocannabinol (THC). Exposure of fetuses to both THC and PCP may predispose them to intrauterine growth restriction, intrauterine fetal demise, and other fetal developmental defects.

Original language	English (US)
Title of host publication	Toxicology Cases for the Clinical and Forensic Laboratory
Publisher	Elsevier
Pages	191-193
Number of pages	3
ISBN (Electronic)	9780128158463
ISBN (Print)	9780128163733
DOIs	https://doi.org/10.1016/B978-0-12-815846-3.00100-9
State	Published - Jan 1 2020

Keywords

Phencyclidine
THC
illicit drug abuse
liquid chromatography
marijuana
tandem mass spectrometry

ASJC Scopus subject areas

General Medicine

Access to Document

10.1016/B978-0-12-815846-3.00100-9

Cite this

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abstract = "The rate of illicit drug abuse during pregnancy has been on the increase in recent years. Intrauterine exposure to illicit drugs may be teratogenic to the fetus. We present a case of a pregnant woman with a history of marijuana and phencyclidine (PCP) abuse. After delivery, PCP was detected in her baby{\textquoteright}s urine using both the screening immunoassay and confirmatory liquid chromatography-tandem mass spectrometry techniques. Meconium sample was sent to a reference laboratory where it was analyzed by immunoassay with positive test results for PCP and tetrahydrocannabinol (THC). Exposure of fetuses to both THC and PCP may predispose them to intrauterine growth restriction, intrauterine fetal demise, and other fetal developmental defects.",

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AU - Ogunbileje, John O.

AU - Young, Paul E.

AU - Okorodudu, Anthony O.

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N2 - The rate of illicit drug abuse during pregnancy has been on the increase in recent years. Intrauterine exposure to illicit drugs may be teratogenic to the fetus. We present a case of a pregnant woman with a history of marijuana and phencyclidine (PCP) abuse. After delivery, PCP was detected in her baby’s urine using both the screening immunoassay and confirmatory liquid chromatography-tandem mass spectrometry techniques. Meconium sample was sent to a reference laboratory where it was analyzed by immunoassay with positive test results for PCP and tetrahydrocannabinol (THC). Exposure of fetuses to both THC and PCP may predispose them to intrauterine growth restriction, intrauterine fetal demise, and other fetal developmental defects.

AB - The rate of illicit drug abuse during pregnancy has been on the increase in recent years. Intrauterine exposure to illicit drugs may be teratogenic to the fetus. We present a case of a pregnant woman with a history of marijuana and phencyclidine (PCP) abuse. After delivery, PCP was detected in her baby’s urine using both the screening immunoassay and confirmatory liquid chromatography-tandem mass spectrometry techniques. Meconium sample was sent to a reference laboratory where it was analyzed by immunoassay with positive test results for PCP and tetrahydrocannabinol (THC). Exposure of fetuses to both THC and PCP may predispose them to intrauterine growth restriction, intrauterine fetal demise, and other fetal developmental defects.

KW - Phencyclidine

KW - THC

KW - illicit drug abuse

KW - liquid chromatography

KW - marijuana

KW - tandem mass spectrometry

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BT - Toxicology Cases for the Clinical and Forensic Laboratory

PB - Elsevier

ER -

Phencyclidine and marijuana exposure in utero

Abstract

Keywords

ASJC Scopus subject areas

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