Phase II study of etoposide and alpha-interferon in patients with advanced measurable colorectal carcinoma

Jaffer A. Ajani; James L. Abbruzzese; Avi B. Markowitz; Yehuda Z. Patt; Karen Daugherty

doi:10.1007/BF00873914

Phase II study of etoposide and alpha-interferon in patients with advanced measurable colorectal carcinoma

Jaffer A. Ajani, James L. Abbruzzese, Avi B. Markowitz, Yehuda Z. Patt, Karen Daugherty

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Based on encouraging in vitro and in vivo data, 14 consecutive patients with measurable metastatic previously untreated colorectal carcinoma were treated with a combination of intravenous etoposide and subcutaneous alpha-interferon. Etoposide was given at 60 mg/m² intravenously on days 1-5 and alpha-interferon at 5 million units/m² subcutaneously on days 1-5; courses were repeated every 21 days. All 14 patients were evaluable for response and toxicity. None of the patients achieved a complete or partial remission. Toxicity of this combination was moderate. Our data suggest that this combination is ineffective against colorectal carcinoma.

Original language	English (US)
Pages (from-to)	67-69
Number of pages	3
Journal	Investigational New Drugs
Volume	11
Issue number	1
DOIs	https://doi.org/10.1007/BF00873914
State	Published - Feb 1993
Externally published	Yes

Keywords

alpha-interferon
colorectal carcinoma
etoposide

ASJC Scopus subject areas

Oncology
Pharmacology
Pharmacology (medical)

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10.1007/BF00873914

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title = "Phase II study of etoposide and alpha-interferon in patients with advanced measurable colorectal carcinoma",

abstract = "Based on encouraging in vitro and in vivo data, 14 consecutive patients with measurable metastatic previously untreated colorectal carcinoma were treated with a combination of intravenous etoposide and subcutaneous alpha-interferon. Etoposide was given at 60 mg/m2 intravenously on days 1-5 and alpha-interferon at 5 million units/m2 subcutaneously on days 1-5; courses were repeated every 21 days. All 14 patients were evaluable for response and toxicity. None of the patients achieved a complete or partial remission. Toxicity of this combination was moderate. Our data suggest that this combination is ineffective against colorectal carcinoma.",

keywords = "alpha-interferon, colorectal carcinoma, etoposide",

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T1 - Phase II study of etoposide and alpha-interferon in patients with advanced measurable colorectal carcinoma

AU - Ajani, Jaffer A.

AU - Abbruzzese, James L.

AU - Markowitz, Avi B.

AU - Patt, Yehuda Z.

AU - Daugherty, Karen

PY - 1993/2

Y1 - 1993/2

N2 - Based on encouraging in vitro and in vivo data, 14 consecutive patients with measurable metastatic previously untreated colorectal carcinoma were treated with a combination of intravenous etoposide and subcutaneous alpha-interferon. Etoposide was given at 60 mg/m2 intravenously on days 1-5 and alpha-interferon at 5 million units/m2 subcutaneously on days 1-5; courses were repeated every 21 days. All 14 patients were evaluable for response and toxicity. None of the patients achieved a complete or partial remission. Toxicity of this combination was moderate. Our data suggest that this combination is ineffective against colorectal carcinoma.

AB - Based on encouraging in vitro and in vivo data, 14 consecutive patients with measurable metastatic previously untreated colorectal carcinoma were treated with a combination of intravenous etoposide and subcutaneous alpha-interferon. Etoposide was given at 60 mg/m2 intravenously on days 1-5 and alpha-interferon at 5 million units/m2 subcutaneously on days 1-5; courses were repeated every 21 days. All 14 patients were evaluable for response and toxicity. None of the patients achieved a complete or partial remission. Toxicity of this combination was moderate. Our data suggest that this combination is ineffective against colorectal carcinoma.

KW - alpha-interferon

KW - colorectal carcinoma

KW - etoposide

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Phase II study of etoposide and alpha-interferon in patients with advanced measurable colorectal carcinoma

Abstract

Keywords

ASJC Scopus subject areas

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