Pharmacotherapy for major depression in children and adolescents

Karen Dineen Wagner

doi:10.1016/j.pnpbp.2005.03.005

Pharmacotherapy for major depression in children and adolescents

Karen Dineen Wagner

Psychiatry and Behavioral Sciences

Research output: Contribution to journal › Review article › peer-review

40 Scopus citations

Abstract

Major depression is a serious illness in children which adversely effects their social, academic, and emotional development. It is essential to identify safe and effective medication for the treatment of this disorder in youths. Only some selective serotonin reuptake inhibitors (citalopram, fluoxetine, sertraline) have demonstrated superiority to placebo on primary outcome measures in acute controlled treatment trials. This article will review acute efficacy studies as well as long-term studies of antidepressants for the treatment of childhood depression. Treatment recommendations are discussed and the issue of suicidality and antidepressants are addressed.

Original language	English (US)
Pages (from-to)	819-826
Number of pages	8
Journal	Progress in Neuro-Psychopharmacology and Biological Psychiatry
Volume	29
Issue number	5
DOIs	https://doi.org/10.1016/j.pnpbp.2005.03.005
State	Published - Jun 2005

Keywords

Antidepressants
Bupropion
Citalopram
Escitalopram
Fluoxetine
Major depression
Mirtazapine
Monoamine oxidase inhibitors
Nefazodone
Paroxetine
Selective serotonin reuptake inhibitors
Sertraline
Suicidality
Venlafaxine

ASJC Scopus subject areas

Pharmacology
Biological Psychiatry

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10.1016/j.pnpbp.2005.03.005

Cite this

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title = "Pharmacotherapy for major depression in children and adolescents",

abstract = "Major depression is a serious illness in children which adversely effects their social, academic, and emotional development. It is essential to identify safe and effective medication for the treatment of this disorder in youths. Only some selective serotonin reuptake inhibitors (citalopram, fluoxetine, sertraline) have demonstrated superiority to placebo on primary outcome measures in acute controlled treatment trials. This article will review acute efficacy studies as well as long-term studies of antidepressants for the treatment of childhood depression. Treatment recommendations are discussed and the issue of suicidality and antidepressants are addressed.",

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AU - Wagner, Karen Dineen

PY - 2005/6

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AB - Major depression is a serious illness in children which adversely effects their social, academic, and emotional development. It is essential to identify safe and effective medication for the treatment of this disorder in youths. Only some selective serotonin reuptake inhibitors (citalopram, fluoxetine, sertraline) have demonstrated superiority to placebo on primary outcome measures in acute controlled treatment trials. This article will review acute efficacy studies as well as long-term studies of antidepressants for the treatment of childhood depression. Treatment recommendations are discussed and the issue of suicidality and antidepressants are addressed.

KW - Antidepressants

KW - Bupropion

KW - Citalopram

KW - Escitalopram

KW - Fluoxetine

KW - Major depression

KW - Mirtazapine

KW - Monoamine oxidase inhibitors

KW - Nefazodone

KW - Paroxetine

KW - Selective serotonin reuptake inhibitors

KW - Sertraline

KW - Suicidality

KW - Venlafaxine

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DO - 10.1016/j.pnpbp.2005.03.005

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AN - SCOPUS:21244443141

SN - 0278-5846

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JO - Progress in Neuro-Psychopharmacology and Biological Psychiatry

JF - Progress in Neuro-Psychopharmacology and Biological Psychiatry

IS - 5

ER -

Pharmacotherapy for major depression in children and adolescents

Abstract

Keywords

ASJC Scopus subject areas

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