Pharmacological properties of mangiferin: bioavailability, mechanisms of action and clinical perspectives

Jelena Zivković, Kammala Ananth Kumar, Rapuru Rushendran, Kaliappan Ilango, Nouran M. Fahmy, Heba A.S. El-Nashar, Mohamed El-Shazly, Shahira M. Ezzat, Guiomar Melgar-Lalanne, Alejandra Romero-Montero, Sheila I. Peña-Corona, Gerardo Leyva-Gomez, Javad Sharifi-Rad, Daniela Calina

Research output: Contribution to journalReview articlepeer-review


This review aims to provide an in-depth analysis of the pharmacological properties of mangiferin, focusing primarily on its bioavailability and mechanisms of action, and its potential therapeutic applications, especially in the context of chronic diseases. We conducted a comprehensive examination of in vitro and in vivo studies, as well as clinical trials involving mangiferin or plant extracts containing mangiferin. The primary source of mangiferin is Mangifera indica, but it’s also found in other plant species from the families Anacardiaceae, Gentianaceae, and Iridaceae. Mangiferin has exhibited a myriad of therapeutic properties, presenting itself as a promising candidate for treating various chronic conditions including neurodegenerative disorders, cardiovascular diseases, renal and pulmonary diseases, diabetes, and obesity. Despite the promising results showcased in many in vitro studies and certain animal studies, the application of mangiferin has been limited due to its poor solubility, absorption, and overall bioavailability. Mangiferin offers significant therapeutic potential in treating a spectrum of chronic diseases, as evidenced by both in vitro and clinical trials. However, the challenges concerning its bioavailability necessitate further research, particularly in optimizing its delivery and absorption, to harness its full medicinal potential. This review serves as a comprehensive update on the health-promoting and therapeutic activities of mangiferin.

Original languageEnglish (US)
Pages (from-to)763-781
Number of pages19
JournalNaunyn-Schmiedeberg's Archives of Pharmacology
Issue number2
StatePublished - Feb 2024
Externally publishedYes


  • Chronic diseases
  • Clinical studies
  • Mangiferin
  • Mechanisms of action
  • Pharmacological properties

ASJC Scopus subject areas

  • Pharmacology


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