Personalization of loco-regional care for primary breast cancer patients (part 2)

Masakazu Toi, Eric P. Winer, John R. Benson, Takashi Inamoto, John F. Forbes, Gunter Von Minckwitz, John Fr Robertson, Stephen R. Grobmyer, Ismail Jatoi, Hironobu Sasano, Ian Kunkler, Alice Y. Ho, Chikako Yamauchi, Louis Wc Chow, Chiun Sheng Huang, Wonshik Han, Shinzaburo Noguchi, Mark D. Pegram, Hideko Yamauchi, Eun Sook LeeAlexey A. Larionov, Jose Lb Bevilacqua, Michio Yoshimura, Tomoharu Sugie, Akira Yamauchi, Ian E. Krop, Dong Young Noh, V. Suzanne Klimberg

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


The loco-regional management of breast cancer is increasingly complex with application of primary systemic therapies, oncoplastic techniques and genetic testing for breast cancer susceptibility. Personalization of loco-regional treatment is integral to optimization of breast cancer care. Clinical and pathological tumor stage, biological features and host factors influence loco-regional treatment strategies and extent of surgical procedures. Key issues including axillary staging, axillary treatment, radiation therapy, primary systemic therapy (PST), preoperative hormonal therapy and genetic predisposition were identified and discussed at the Kyoto Breast Cancer Consensus Conference (KBCCC2014). In the second of a two part conference scene, consensus recommendations for radiation treatment, primary systemic therapies and management of genetic predisposition are reported and focus on the following topics: influence of both clinical response to PST and stage at presentation on recommendations for postmastectomy radiotherapy; use of regional nodal irradiation in selected node-positive patients and those with adverse pathological factors; extent of surgical resection following downstaging of tumors with PST; use of preoperative hormonal therapy in premenopausal women with larger, node-negative luminal A-like tumors and managing increasing demands for contralateral prophylactic mastectomy in patients with a unilateral sporadic breast cancer.

Original languageEnglish (US)
Pages (from-to)1301-1305
Number of pages5
JournalFuture Oncology
Issue number9
StatePublished - May 1 2015
Externally publishedYes


  • BRCA1/2
  • breast cancer
  • luminal type
  • postmastectomy radiation therapy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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