Persistent shedding of West Nile virus in urine of experimentally infected hamsters

Jessica H. Tonry, Shu Yuan Xiao, Marina Siirin, Hongli Chen, Amelia P.A. Travassos Da Rosa, Robert B. Tesh

Research output: Contribution to journalArticlepeer-review

90 Scopus citations


Adult hamsters that survived experimental West Nile virus (WNV) infection developed persistent viruria. Infectious WNV could be cultured from their urine for up to 52 days. Immunohistochemical examination of kidneys of viruric animals showed foci of WNV antigen in renal tubular epithelial and vascular endothelial cells. These findings are compatible with virus replication and persistent infection of renal epithelial cells. The potential clinical and virologic significance of these findings as well as their possible epidemiologic importance are discussed.

Original languageEnglish (US)
Pages (from-to)320-324
Number of pages5
JournalAmerican Journal of Tropical Medicine and Hygiene
Issue number3
StatePublished - Mar 2005
Externally publishedYes

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology
  • Parasitology


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