Peroxynitrite production and activation of poly (adenosine diphosphate ribose) synthetase in spinal cord injury

G. S. Scott; L. B. Jakeman; B. T. Stokes; C. Szabó

doi:10.1002/1531-8249(199901)45:1<120::AID-ART18>3.0.CO;2-I

Peroxynitrite production and activation of poly (adenosine diphosphate ribose) synthetase in spinal cord injury

G. S. Scott, L. B. Jakeman, B. T. Stokes, C. Szabó

Research output: Contribution to journal › Article › peer-review

79 Scopus citations

Abstract

Peroxynitrite formation and the subsequent activation of the nuclear enzyme, poly (adenosine diphosphate [ADP]-ribose) synthetase (PARS), has been implicated in the pathogenesis of several neurodegenerative disorders. Here, we demonstrate that nitrotyrosine, an indicator of peroxynitrite generation, and poly (ADP) ribose, a marker of PARS activation, were selectively localized within tissues from spinal cord-injured rats. Our data implicate a role for peroxynitrite production and PARS activation in the development of spinal cord trauma.

Original language	English (US)
Pages (from-to)	120-124
Number of pages	5
Journal	Annals of Neurology
Volume	45
Issue number	1
DOIs	https://doi.org/10.1002/1531-8249(199901)45:1<120::AID-ART18>3.0.CO;2-I
State	Published - 1999
Externally published	Yes

ASJC Scopus subject areas

Neurology
Clinical Neurology

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10.1002/1531-8249(199901)45:1<120::AID-ART18>3.0.CO;2-I

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abstract = "Peroxynitrite formation and the subsequent activation of the nuclear enzyme, poly (adenosine diphosphate [ADP]-ribose) synthetase (PARS), has been implicated in the pathogenesis of several neurodegenerative disorders. Here, we demonstrate that nitrotyrosine, an indicator of peroxynitrite generation, and poly (ADP) ribose, a marker of PARS activation, were selectively localized within tissues from spinal cord-injured rats. Our data implicate a role for peroxynitrite production and PARS activation in the development of spinal cord trauma.",

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AU - Jakeman, L. B.

AU - Stokes, B. T.

AU - Szabó, C.

PY - 1999

Y1 - 1999

N2 - Peroxynitrite formation and the subsequent activation of the nuclear enzyme, poly (adenosine diphosphate [ADP]-ribose) synthetase (PARS), has been implicated in the pathogenesis of several neurodegenerative disorders. Here, we demonstrate that nitrotyrosine, an indicator of peroxynitrite generation, and poly (ADP) ribose, a marker of PARS activation, were selectively localized within tissues from spinal cord-injured rats. Our data implicate a role for peroxynitrite production and PARS activation in the development of spinal cord trauma.

AB - Peroxynitrite formation and the subsequent activation of the nuclear enzyme, poly (adenosine diphosphate [ADP]-ribose) synthetase (PARS), has been implicated in the pathogenesis of several neurodegenerative disorders. Here, we demonstrate that nitrotyrosine, an indicator of peroxynitrite generation, and poly (ADP) ribose, a marker of PARS activation, were selectively localized within tissues from spinal cord-injured rats. Our data implicate a role for peroxynitrite production and PARS activation in the development of spinal cord trauma.

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Peroxynitrite production and activation of poly (adenosine diphosphate ribose) synthetase in spinal cord injury

Abstract

ASJC Scopus subject areas

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