Percutaneous Repair of Mitral Regurgitation: A Comprehensive Review of Literature

Salman Salehin, Syed Mustajab Hasan, Steven Mai, Peter Rasmussen, Ahmad Shahzad, Ramy Abdelmaseih, Deaa Abu Jazar, Mostafa Shalaby, Afaq Motiwala, Syed Gilani, Wissam I. Khalife

Research output: Contribution to journalReview articlepeer-review


Mitral regurgitation is the most common valvular disease in the US and the second most common worldwide. Left untreated, it can lead to the development of heart failure, giving rise to increased mortality rates. Mitral valve intervention is usually indicated in severe mitral regurgitation at the onset of symptoms, even if the function of the left ventricle is preserved. A surgical approach is generally favored according to current guidelines, with excellent clinical outcomes. However, the emergence of novel data from contemporary trials indicates that percutaneous, catheter-based approach may have similar improvements in mortality outcomes while maintaining a superior safety profile when compared to the surgical approach. Here, we discuss transcatheter mitral valve repair as a treatment option for mitral regurgitation and summarize the major clinical trials which were recently conducted on transcatheter repair.

Original languageEnglish (US)
Article number101338
JournalCurrent Problems in Cardiology
Issue number11
StatePublished - Nov 2022
Externally publishedYes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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