Percutaneous Mitral Valve Repair in Cardiac Amyloidosis and Severe Mitral Regurgitation

Ravi A. Thakker; Ayman Elbadawi; Aiham Albaeni; Syed Mustajab Hasan; Krishna H. Suthar; Shreyas Modi; Rafic Berbarie; Wissam Khalife; Khaled F. Chatila

doi:10.1016/j.cpcardiol.2021.100881

Percutaneous Mitral Valve Repair in Cardiac Amyloidosis and Severe Mitral Regurgitation

Ravi A. Thakker, Ayman Elbadawi, Aiham Albaeni, Syed Mustajab Hasan, Krishna H. Suthar, Shreyas Modi, Rafic Berbarie, Wissam Khalife, Khaled F. Chatila

Internal Medicine

Research output: Contribution to journal › Review article › peer-review

Abstract

Amyloidosis is an infiltrative disease with severe impact on the cardiac anatomy resulting in structural changes¹. Mitral valve insult from the infiltrative process, although rare, has been known to cause severe mitral regurgitation⁴. Due to underlying comorbidities these patients may not be surgical candidates.¹⁷^,¹⁸^,¹⁹^,²⁰ The role of percutaneous mitral valve repair in cardiac amyloidosis has been described in a few prior cases.⁴^,¹⁵ We review the epidemiology, diagnosis, and treatment of cardiac amyloidosis. We also highlight prior cases described in the literature of cardiac amyloidosis and severe mitral regurgitation, while discussing the role of percutaneous mitral valve repair in these patients.

Original language	English (US)
Article number	100881
Journal	Current Problems in Cardiology
Volume	47
Issue number	9
DOIs	https://doi.org/10.1016/j.cpcardiol.2021.100881
State	Published - Sep 2022

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/j.cpcardiol.2021.100881

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title = "Percutaneous Mitral Valve Repair in Cardiac Amyloidosis and Severe Mitral Regurgitation",

abstract = "Amyloidosis is an infiltrative disease with severe impact on the cardiac anatomy resulting in structural changes1. Mitral valve insult from the infiltrative process, although rare, has been known to cause severe mitral regurgitation4. Due to underlying comorbidities these patients may not be surgical candidates.17,18,19,20 The role of percutaneous mitral valve repair in cardiac amyloidosis has been described in a few prior cases.4,15 We review the epidemiology, diagnosis, and treatment of cardiac amyloidosis. We also highlight prior cases described in the literature of cardiac amyloidosis and severe mitral regurgitation, while discussing the role of percutaneous mitral valve repair in these patients.",

author = "Thakker, {Ravi A.} and Ayman Elbadawi and Aiham Albaeni and Hasan, {Syed Mustajab} and Suthar, {Krishna H.} and Shreyas Modi and Rafic Berbarie and Wissam Khalife and Chatila, {Khaled F.}",

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year = "2022",

month = sep,

doi = "10.1016/j.cpcardiol.2021.100881",

language = "English (US)",

volume = "47",

journal = "Current Problems in Cardiology",

issn = "0146-2806",

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TY - JOUR

T1 - Percutaneous Mitral Valve Repair in Cardiac Amyloidosis and Severe Mitral Regurgitation

AU - Thakker, Ravi A.

AU - Elbadawi, Ayman

AU - Albaeni, Aiham

AU - Hasan, Syed Mustajab

AU - Suthar, Krishna H.

AU - Modi, Shreyas

AU - Berbarie, Rafic

AU - Khalife, Wissam

AU - Chatila, Khaled F.

PY - 2022/9

Y1 - 2022/9

N2 - Amyloidosis is an infiltrative disease with severe impact on the cardiac anatomy resulting in structural changes1. Mitral valve insult from the infiltrative process, although rare, has been known to cause severe mitral regurgitation4. Due to underlying comorbidities these patients may not be surgical candidates.17,18,19,20 The role of percutaneous mitral valve repair in cardiac amyloidosis has been described in a few prior cases.4,15 We review the epidemiology, diagnosis, and treatment of cardiac amyloidosis. We also highlight prior cases described in the literature of cardiac amyloidosis and severe mitral regurgitation, while discussing the role of percutaneous mitral valve repair in these patients.

AB - Amyloidosis is an infiltrative disease with severe impact on the cardiac anatomy resulting in structural changes1. Mitral valve insult from the infiltrative process, although rare, has been known to cause severe mitral regurgitation4. Due to underlying comorbidities these patients may not be surgical candidates.17,18,19,20 The role of percutaneous mitral valve repair in cardiac amyloidosis has been described in a few prior cases.4,15 We review the epidemiology, diagnosis, and treatment of cardiac amyloidosis. We also highlight prior cases described in the literature of cardiac amyloidosis and severe mitral regurgitation, while discussing the role of percutaneous mitral valve repair in these patients.

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U2 - 10.1016/j.cpcardiol.2021.100881

DO - 10.1016/j.cpcardiol.2021.100881

M3 - Review article

C2 - 34078542

AN - SCOPUS:85107142753

SN - 0146-2806

VL - 47

JO - Current Problems in Cardiology

JF - Current Problems in Cardiology

IS - 9

M1 - 100881

ER -

Percutaneous Mitral Valve Repair in Cardiac Amyloidosis and Severe Mitral Regurgitation

Abstract

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