Peptide YY

G. H. Greeley

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


The intention of this report is to give an overview of the gastrointestinal peptide, peptide YY (PYY). PYY is a recently isolated gut peptide that is primarily found in the distal bowel; it is localized in open type endocrine cells of the mucosa. Exogenous administration of PYY results in a variety of effects on the GI tract and pancreas reminiscent of a gut factor called 'pancreatone' that was isolated in crude form only. Plasma levels of PYY increase in response to an oral meal, especially fat. Because PYY exerts numerous inhibitory actions on GI function and slows movement of chyme down the GI tract, PYY may play an important role as an 'ideal brake.'

Original languageEnglish (US)
Pages (from-to)89-92
Number of pages4
JournalBiomedical Research
Issue numberSUPPL. 3
StatePublished - 1993
Externally publishedYes

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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