Pathophysiology of the Burn Scar

Hal Hawkins, Jayson Jay, Celeste C. Finnerty

Research output: Chapter in Book/Report/Conference proceedingChapter


This chapter reviews current knowledge of the process of wound healing in humans and animals, with special emphasis on abnormal long-term responses to thermal injury. Delays or defects in wound repair lead to aberrant wound healing, and frequently result in pathologic scarring following a severe burn injury. Here we review the wound healing process, including the roles of fibroblasts, keratinocytes, and immune cells in achieving wound closure, the factors that delay wound-healing and result in hypertrophic scarring, and the key pathologic features of hypertrophic scars. Experimental models of hypertrophic scarring—from cell culture to preclinical models to human models—are presented, along with a discussion of areas for further research.

Original languageEnglish (US)
Title of host publicationTotal Burn Care, Fifth Edition
ISBN (Electronic)9780323476614
ISBN (Print)9780323497428
StatePublished - Jan 1 2017


  • Duroc pig
  • Hypertrophic scar
  • cicatrix
  • collagen
  • cytokines and growth factors
  • fibroblasts
  • immune cells
  • inflammation
  • keratinocytes
  • mast cells

ASJC Scopus subject areas

  • General Medicine


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