Pathogenesis of Zika Virus Infection

Maria I. Giraldo, Maria Gonzalez-Orozco, Ricardo Rajsbaum Gorodezky

Research output: Contribution to journalReview articlepeer-review

Abstract

Zika virus (ZIKV) is an emerging virus from the Flaviviridae family that is transmitted to humans by mosquito vectors and represents an important health problem. Infections in pregnant women are of major concern because of potential devastating consequences during pregnancy and have been associated with microcephaly in newborns. ZIKV has a unique ability to use the host machinery to promote viral replication in a tissue-specific manner, resulting in characteristic pathological disorders. Recent studies have proposed that the host ubiquitin system acts as a major determinant of ZIKV tropism by providing the virus with an enhanced ability to enter new cells. In addition, ZIKV has developed mechanisms to evade the host immune response, thereby allowing the establishment of viral persistence and enhancing viral pathogenesis. We discuss recent reports on the mechanisms used by ZIKV to replicate efficiently, and we highlight potential new areas of research for the development of therapeutic approaches.

Original languageEnglish (US)
Pages (from-to)181-203
Number of pages23
JournalAnnual Review of Pathology: Mechanisms of Disease
Volume18
DOIs
StatePublished - Jan 24 2023

Keywords

  • TRIM7
  • Zika virus
  • antagonism of immune responses
  • pathogenesis
  • tropism
  • ubiquitin

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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