TY - JOUR
T1 - Pancreatic Secretion in Man
T2 - Effect of Fasting, Drugs, Pancreatic Enzymes, and Somatostatin
AU - Anand, Bhupinderjit S.
AU - Goodgame, Richard
AU - Graham, David Y.
PY - 1994/2
Y1 - 1994/2
N2 - The inhibitory effecl of different drugs on pancreatic secretions was assessed in a patient with a posttraumatic pancreatic‐cutaneous fistula. The various drugs examined were: pancreatic enzymes, cimetidine, verapamil, propantheline, acetazolamide., and somatostatin analog octreotide. Only fasting and octreotide reduced pancreatic secretion. The optimum dose of octreotide was 50 g bid given subcutaneous I y; increasing the dose up to 100 Hg tid had no additional benefit. A stable pancreatic‐cutaneous fistula is an excellent model to assess the effect of different therapeutic measures on pancreatic secretion.
AB - The inhibitory effecl of different drugs on pancreatic secretions was assessed in a patient with a posttraumatic pancreatic‐cutaneous fistula. The various drugs examined were: pancreatic enzymes, cimetidine, verapamil, propantheline, acetazolamide., and somatostatin analog octreotide. Only fasting and octreotide reduced pancreatic secretion. The optimum dose of octreotide was 50 g bid given subcutaneous I y; increasing the dose up to 100 Hg tid had no additional benefit. A stable pancreatic‐cutaneous fistula is an excellent model to assess the effect of different therapeutic measures on pancreatic secretion.
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U2 - 10.1111/j.1572-0241.1994.tb07825.x
DO - 10.1111/j.1572-0241.1994.tb07825.x
M3 - Article
C2 - 7905706
AN - SCOPUS:0028107415
SN - 0002-9270
VL - 89
SP - 267
EP - 270
JO - The American Journal of Gastroenterology
JF - The American Journal of Gastroenterology
IS - 2
ER -