TY - CHAP
T1 - Overview
AU - Wiktorowicz, John E.
PY - 2014
Y1 - 2014
N2 - Although broadly defined in the literature, for the purpose of this section, we define systems biology as the description of the dynamic genomic, proteomic, and metabolomic processes integrated into a functional model of the cell, organelle, or tissue that is capable of accurately tracking the biological system's response to environmental perturbations. The goal of this section is to complete the tripartite description of asthma systems biology, initiated by the previous section (Section II: Genetics and Genomics of Asthma), by reviewing the recent literature-the types and methods of sample collection, processing, analysis, and instrumentation-of metabolomic and proteomic investigations, including functional proteomic studies of the asthma innate immune response and glucocorticoid (GC) receptor signaling with reference to GC resistance in severe asthma.
AB - Although broadly defined in the literature, for the purpose of this section, we define systems biology as the description of the dynamic genomic, proteomic, and metabolomic processes integrated into a functional model of the cell, organelle, or tissue that is capable of accurately tracking the biological system's response to environmental perturbations. The goal of this section is to complete the tripartite description of asthma systems biology, initiated by the previous section (Section II: Genetics and Genomics of Asthma), by reviewing the recent literature-the types and methods of sample collection, processing, analysis, and instrumentation-of metabolomic and proteomic investigations, including functional proteomic studies of the asthma innate immune response and glucocorticoid (GC) receptor signaling with reference to GC resistance in severe asthma.
KW - Airway inflammation
KW - Asthma
KW - Bronchoscopic microsampling
KW - Broncoalveolar lavage
KW - Epithelial lining fluid
KW - Exhaled breath condensate
KW - Induced sputum
KW - Proteomics
KW - Sample prep
KW - Size-exclusion chromatography
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U2 - 10.1007/978-1-4614-8603-9_12
DO - 10.1007/978-1-4614-8603-9_12
M3 - Chapter
C2 - 24162910
AN - SCOPUS:84934440699
SN - 9781461486022
T3 - Advances in Experimental Medicine and Biology
SP - 203
EP - 205
BT - Heterogeneity in Asthma
PB - Springer New York LLC
ER -