Ovarian strumal carcinoid: Immunohistochemical, ultrastructural, and clinicopathologic observations

Russell R. Snyder, F. A. Tavassoli

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


A review of 13 ovarian strumal carcinoids in the files of the Armed Forces Institute of Pathology has established further evidence that these tumors have both endocrine and neuroendocrine differentiation. The two functional routes of differentiation occur even within individual tumor cells. Immunohistochemical reaction for thyroglobulin was positive in the strumal regions of all 12 cases tested. This positivity was also present in transitional zones where the thyroid follicles merged with nests of carcinoid cells. Electron microscopy performed in six cases showed cells with neuroendocrine granules in the thyroid follicles; these cells resemble the C-cells of the normal thyroid gland. An immunoperoxidase reaction for calcitonin, however, revealed no positivity in any of the cells corresponding to the neuroendocrine cells within the follicles or those in the carcinoid component. Variable positivity for serotonin was observed, however. It is proposed that cells within the struma that have morphologic similarities to the C-cells of the thyroid give rise to the carcinoid component. These cells appear capable of producing thyroglobulin as well as neuroendocrine granules.

Original languageEnglish (US)
Pages (from-to)187-201
Number of pages15
JournalInternational Journal of Gynecological Pathology
Issue number3
StatePublished - Sep 1986
Externally publishedYes


  • Neuroendocrine
  • Strumal carcinoid

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Obstetrics and Gynecology


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