Outcomes of patients with COPD hospitalized for coronavirus disease 2019

Daniel A. Puebla Neira, Abigail Watts, Justin Seashore, Alexander Duarte, Shawn P. Nishi, Efstathia Polychronopoulou, Yong Fang Kuo, Jacques Baillargeon, Gulshan Sharma

Research output: Contribution to journalArticlepeer-review


Rationale: There is controversy concerning the association of chronic obstructive pulmonary disease (COPD) as an independent risk factor for mortality in patients hospitalized with coronavirus disease 2019 (COVID-19). We hypothesize that patients with COPD hospitalized for COVID-19 have increased mortality risk. Objective: To assess whether COPD increased the risk of mortality among patients hospitalized for COVID-19. Methods: We conducted a retrospective cohort analysis of patients with COVID-19 between February 10, 2020, and November 10, 2020, and hospitalized within 14 days of diagnosis. Electronic health records from U.S. facilities (Optum COVID-19 data) were used. Results: In our cohort of 31,526 patients, 3030 (9.6%) died during hospitalization. Mortality in patients with COPD was higher than that of patients without COPD, 14.02% and 8.8%, respectively. Univariate (odds ratio [OR] 1.68; 95% confidence interval [CI] 1.54 to1.84) and multivariate (OR 1.33; 95% CI 1.18 to1.50) analysis showed that patients with COPD had greater odds of death due to COVID-19 than patients without COPD. We found significant interactions between COPD and sex and COPD and age. Specifically, the increased mortality risk associated with COPD was observed among female (OR 1.62; 95% CI 1.36 to 1.95) but not male patients (OR 1.14; 95% CI 0.97 to 1.34); and in patients aged 40 to 64 (OR 1.42; 95% CI 1.07 to 1.90) and 65 to 79 (OR 1.48; 95% CI 1.23 to 1.78) years. Conclusions: COPD is an independent risk factor for death in adults aged 40 to 79 years hospitalized with COVID-19 infection.

Original languageEnglish (US)
Pages (from-to)517-527
Number of pages11
JournalChronic Obstructive Pulmonary Diseases
Issue number4
StatePublished - 2021


  • COPD
  • COVID-19
  • Chronic obstructive pulmonary disease
  • Mortality

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


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