Abstract
We discuss recent experiments and theories concerning protein col lapse and folding. Experiments using multicomponent solutions have revealed much about the mechanism of folding. Simulation and theory have been used to interpret thermodynamic and fluorescence correlation spectroscopy experi mental results. We consider the theoretical arguments using variations of the free energy with respect to fluctuations in number and composition to consider recent experiments. We find new measures of protein stability tendencies offer a different view than the often poorly defined hydrophobic effect.
| Original language | English (US) |
|---|---|
| Title of host publication | Fluctuation Theory of Solutions |
| Subtitle of host publication | Applications in Chemistry, Chemical Engineering, and Biophysics |
| Publisher | CRC Press |
| Pages | 309-323 |
| Number of pages | 15 |
| ISBN (Electronic) | 9781439899236 |
| ISBN (Print) | 9781439899229 |
| State | Published - Apr 19 2016 |
ASJC Scopus subject areas
- General Medicine
- General Biochemistry, Genetics and Molecular Biology
- General Physics and Astronomy
- General Chemistry