Osmophobics and hydrophobics: The changing landscape of protein folding

Matthew Auton, B. Montgomery Pettitt

Research output: Chapter in Book/Report/Conference proceedingChapter


We discuss recent experiments and theories concerning protein col lapse and folding. Experiments using multicomponent solutions have revealed much about the mechanism of folding. Simulation and theory have been used to interpret thermodynamic and fluorescence correlation spectroscopy experi mental results. We consider the theoretical arguments using variations of the free energy with respect to fluctuations in number and composition to consider recent experiments. We find new measures of protein stability tendencies offer a different view than the often poorly defined hydrophobic effect.

Original languageEnglish (US)
Title of host publicationFluctuation Theory of Solutions
Subtitle of host publicationApplications in Chemistry, Chemical Engineering, and Biophysics
PublisherCRC Press
Number of pages15
ISBN (Electronic)9781439899236
ISBN (Print)9781439899229
StatePublished - Apr 19 2016

ASJC Scopus subject areas

  • General Medicine
  • General Biochemistry, Genetics and Molecular Biology
  • General Physics and Astronomy
  • General Chemistry


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