Opioid receptors of human placental villi modulate acetylcholine release

Mahmoud S. Ahmed, Mark A. Horst

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


The human placental villous tissue contains components of the cholinergic system and opioid receptors of the kappa type. In vitro stimulation of the villous tissue releases acetylcholine in organ baths. A selective kappa agonist, ethylketocyclazocine, inhibits the release of acetylcholine. This inhibition is reversed by the antagonist Mr 2266. The antagonist alone stimulates the release of acetylcholine 18-fold over control. These results demonstrate an interaction between the placental opioid receptors and the cholinergic system in a non-neural tissue. The modulation of acetylcholine release by endogenous opioid peptides could be one of the in vivo functions of placental opioid receptors.

Original languageEnglish (US)
Pages (from-to)535-540
Number of pages6
JournalLife Sciences
Issue number6
StatePublished - Aug 11 1986
Externally publishedYes

ASJC Scopus subject areas

  • General Pharmacology, Toxicology and Pharmaceutics
  • General Biochemistry, Genetics and Molecular Biology


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