TY - JOUR
T1 - One more piece in the VACV ecological puzzle
T2 - Could peridomestic rodents be the link between wildlife and bovine vaccinia outbreaks in Brazil?
AU - Abrahão, Jônatas S.
AU - Guedes, Maria Isabel M.
AU - Trindade, Giliane S.
AU - Fonseca, Flávio G.
AU - Campos, Rafael K.
AU - Mota, Bruno F.
AU - Lobato, Zélia I.P.
AU - Silva-Fernandes, André T.
AU - Rodrigues, Gisele O.L.
AU - Lima, Larissa S.
AU - Ferreira, Paulo C.P.
AU - Bonjardim, Cláudio A.
AU - Kroon, Erna G.
PY - 2009/10/19
Y1 - 2009/10/19
N2 - Background: Despite the fact that smallpox eradication was declared by the World Health Organization (WHO) in 1980, other poxviruses have emerged and re-emerged, with significant public health and economic impacts. Vaccinia virus (VACV), a poxvirus used during the WHO smallpox vaccination campaign, has been involved in zoonotic infections in Brazilian rural areas (Bovine Vaccinia outbreaks - BV), affecting dairy cattle and milkers. Little is known about VACV's natural hosts and its epidemiological and ecological characteristics. Although VACV was isolated and/or serologically detected in Brazilian wild animals, the link between wildlife and farms has not yet been elucidated. Methodology/Principal Findings: In this study, we describe for the first time, to our knowledge, the isolation of a VACV (Mariana virus - MARV) from a mouse during a BV outbreak. Genetic data, in association with biological assays, showed that this isolate was the same etiological agent causing exanthematic lesions observed in the cattle and human inhabitants of a particular BV-affected area. Phylogenetic analysis grouped MARV with other VACV isolated during BV outbreaks. Conclusion/Significance: These data provide new biological and epidemiological information on VACV and lead to an interesting question: could peridomestic rodents be the link between wildlife and BV outbreaks?
AB - Background: Despite the fact that smallpox eradication was declared by the World Health Organization (WHO) in 1980, other poxviruses have emerged and re-emerged, with significant public health and economic impacts. Vaccinia virus (VACV), a poxvirus used during the WHO smallpox vaccination campaign, has been involved in zoonotic infections in Brazilian rural areas (Bovine Vaccinia outbreaks - BV), affecting dairy cattle and milkers. Little is known about VACV's natural hosts and its epidemiological and ecological characteristics. Although VACV was isolated and/or serologically detected in Brazilian wild animals, the link between wildlife and farms has not yet been elucidated. Methodology/Principal Findings: In this study, we describe for the first time, to our knowledge, the isolation of a VACV (Mariana virus - MARV) from a mouse during a BV outbreak. Genetic data, in association with biological assays, showed that this isolate was the same etiological agent causing exanthematic lesions observed in the cattle and human inhabitants of a particular BV-affected area. Phylogenetic analysis grouped MARV with other VACV isolated during BV outbreaks. Conclusion/Significance: These data provide new biological and epidemiological information on VACV and lead to an interesting question: could peridomestic rodents be the link between wildlife and BV outbreaks?
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U2 - 10.1371/journal.pone.0007428
DO - 10.1371/journal.pone.0007428
M3 - Article
C2 - 19838293
AN - SCOPUS:70449397521
SN - 1932-6203
VL - 4
JO - PloS one
JF - PloS one
IS - 10
M1 - e7428
ER -