NS5 from dengue virus serotype 2 can adopt a conformation analogous to that of its zika virus and Japanese encephalitis virus homologues

Keyphrases

• Japanese Encephalitis Virus 100%
• Zika Virus 100%
• NS5A 100%
• Dengue Virus Serotype 2 100%
• Virus Encephalitis 100%
• Linker 43%
• DENV-2 43%
• Flavivirus 26%
• RNA-dependent RNA Polymerase (RdRP) 8%
• Vaccine Design 8%
• Methyltransferase 8%
• Heterotypic 8%
• Dengue Virus Serotype 3 8%
• Replication Complex 4%
• RNA Replication 4%
• Amino Acids 4%
• Protein-protein Interaction 4%
• Dengue Virus 4%
• Polymerase 4%
• Virus Replication 4%
• Polymerase Domain 4%
• Methyltransferase Domain 4%
• Viral Proteins 4%
• Virus 4%
• Antiviral Vaccines 4%
• Non-structural Protein 4%
• Enzymatic Activity 4%
• Enzyme Activity 4%
• Replicon 4%
• Drug Target 4%
• Human Pathogens 4%
• Host Cell Proteins 4%
• Structure Dynamics 4%
• Inhibitor Design 4%
• Structure Evolution 4%
• Minimal Impact 4%
• Relative Orientation 4%
• Interdomain Linker 4%
• Crystalline Structure 4%
• RNA-dependent RNA Polymerase Activity 4%
• Antiviral Inhibitor 4%

Biochemistry, Genetics and Molecular Biology

• Protein 100%
• Dengue Virus 100%
• Conformation 100%
• Japanese Encephalitis Virus 100%
• Serotype 100%
• Zika Virus 100%
• Dengue Virus 2 34%
• Flavivirus 20%
• Methyltransferase 10%
• RNA-dependent RNA Polymerase 10%
• Dynamics 6%
• Enzyme Activity 6%
• Human 3%
• Development 3%
• Light 3%
• Growth 3%
• Amino Acids 3%
• Virus 3%
• RNA Replication 3%
• Crystal Structure 3%
• Length 3%
• Virus Replication 3%
• Polymerase 3%
• Host 3%
• Infectious Agent 3%
• N-Terminus 3%
• Replicon 3%
• Crystal Structure 3%
• C-Terminus 3%
• Evolution 3%
• Dengue Virus 4 3%
• Dengue Virus 1 3%

INIS

• proteins 100%
• viruses 100%
• encephalitis 100%
• zika virus 100%
• rna polymerases 13%
• rna 10%
• methyl transferases 10%
• interactions 6%
• in vitro 6%
• design 6%
• vaccines 6%
• dynamics 6%
• humans 3%
• drugs 3%
• growth 3%
• strains 3%
• amino acids 3%
• host 3%
• length 3%
• crystal structure 3%
• pathogens 3%
• crystallography 3%
• enzyme activity 3%
• replicons 3%
• orientation 3%