Abstract
THE diverse functions of T lymphocytes in the defense of the host are mediated by multiple subpopulations that are often classified by the pattern in which they express surface structures. Most mature, post-thymic T cells bear the alpha/beta form of the T-cell receptor for antigen (TCR α/β). These cells also bear either CD4 or CD8 — glycoproteins characteristic of the helper-inducer and suppressor-cytotoxic subpopulations, respectively. A minor subpopulation of circulating T cells bears an alternative, gamma/delta form of the T-cell receptor for antigen (TCR γ/δ), but most of these cells express neither CD4 nor CD8.1 Both TCR α/β and TCR…
Original language | English (US) |
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Pages (from-to) | 370-374 |
Number of pages | 5 |
Journal | New England Journal of Medicine |
Volume | 321 |
Issue number | 6 |
DOIs | |
State | Published - Aug 10 1989 |
ASJC Scopus subject areas
- General Medicine