Novel predictive and therapeutic options for better pregnancy outcome in frozen embryo transfer cycles

Warren J. Huber, May Tal Sauerbrun-Cutler, Paula M. Krueger, Surendra Sharma

Research output: Contribution to journalArticlepeer-review

Abstract

Since 1978, in the first decades of in vitro fertilization (IVF), the use of ovarian hyperstimulation allowed for the development and transfer of multiple embryos. As IVF technology improved, the number of multiple pregnancies increased, which led to gradual reduction in the number of embryos that were transferred. Embryo freezing (vitrification) was recommended to allow subsequent transfer if the fresh cycle was unsuccessful. However, experimentation has continued to improve pregnancy outcomes. We discuss here the significance of frozen embryo transfer cycle and the impact of uterine and peripheral immunity dominated by NK cells and regulatory T cells and human chorionic gonadotropin on pregnancy outcome in this innovative mode of IVF therapy.

Original languageEnglish (US)
Article numbere13300
JournalAmerican Journal of Reproductive Immunology
Volume85
Issue number4
DOIs
StatePublished - Apr 2021
Externally publishedYes

Keywords

  • NK cells
  • endometrial receptivity
  • frozen embryo transfer
  • human chorionic gonadotropin
  • in vitro fertilization
  • regulatory T cells

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Reproductive Medicine
  • Obstetrics and Gynecology

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