Novel orthohepeviruses in wild rodents from São Paulo State, Brazil

William Marciel de Souza; Marilia Farignoli Romeiro; Gilberto Sabino-Santos; Felipe Gonçalves Motta Maia; Marcilio Jorge Fumagalli; Sejal Modha; Marcio Roberto Teixeira Nunes; Pablo Ramiro Murcia; Luiz Tadeu Moraes Figueiredo

doi:10.1016/j.virol.2018.03.025

Novel orthohepeviruses in wild rodents from São Paulo State, Brazil

William Marciel de Souza, Marilia Farignoli Romeiro, Gilberto Sabino-Santos, Felipe Gonçalves Motta Maia, Marcilio Jorge Fumagalli, Sejal Modha, Marcio Roberto Teixeira Nunes, Pablo Ramiro Murcia, Luiz Tadeu Moraes Figueiredo

Research output: Contribution to journal › Article › peer-review

Abstract

The Hepeviridae comprise single-stranded positive-sense RNA viruses classified into two genera, Orthohepevirus and Piscihepevirus. Orthohepeviruses have a wide host range that includes rodents, but previous studies had been restricted to rodents of the Muridae family. In this study, we applied a high-throughput sequencing approach to examine the presence of orthohepeviruses in rodents from São Paulo State, Brazil. We also used RT-PCR to determine the frequency of orthohepeviruses in our sampled population. We identified novel orthohepeviruses in blood samples derived from Necromys lasiurus (1.19%) and Calomys tener (3.66%). Therefore, our results expand the host range and viral diversity of the Hepeviridae family.

Original language	English (US)
Pages (from-to)	12-16
Number of pages	5
Journal	Virology
Volume	519
DOIs	https://doi.org/10.1016/j.virol.2018.03.025
State	Published - Jun 2018
Externally published	Yes

Keywords

Hepatitis E virus
Hepeviridae
Orthohepevirus
Rodent-borne viruses
Viral hepatitis

ASJC Scopus subject areas

Virology

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10.1016/j.virol.2018.03.025

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@article{bb1e8a608ede4d41a9ccb19ea7804938,

title = "Novel orthohepeviruses in wild rodents from S{\~a}o Paulo State, Brazil",

abstract = "The Hepeviridae comprise single-stranded positive-sense RNA viruses classified into two genera, Orthohepevirus and Piscihepevirus. Orthohepeviruses have a wide host range that includes rodents, but previous studies had been restricted to rodents of the Muridae family. In this study, we applied a high-throughput sequencing approach to examine the presence of orthohepeviruses in rodents from S{\~a}o Paulo State, Brazil. We also used RT-PCR to determine the frequency of orthohepeviruses in our sampled population. We identified novel orthohepeviruses in blood samples derived from Necromys lasiurus (1.19%) and Calomys tener (3.66%). Therefore, our results expand the host range and viral diversity of the Hepeviridae family.",

keywords = "Hepatitis E virus, Hepeviridae, Orthohepevirus, Rodent-borne viruses, Viral hepatitis",

author = "{de Souza}, {William Marciel} and Romeiro, {Marilia Farignoli} and Gilberto Sabino-Santos and Maia, {Felipe Gon{\c c}alves Motta} and Fumagalli, {Marcilio Jorge} and Sejal Modha and Nunes, {Marcio Roberto Teixeira} and Murcia, {Pablo Ramiro} and Figueiredo, {Luiz Tadeu Moraes}",

note = "Publisher Copyright: {\textcopyright} 2018 Elsevier Inc.",

year = "2018",

month = jun,

doi = "10.1016/j.virol.2018.03.025",

language = "English (US)",

volume = "519",

pages = "12--16",

journal = "Virology",

issn = "0042-6822",

publisher = "Academic Press Inc.",

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T1 - Novel orthohepeviruses in wild rodents from São Paulo State, Brazil

AU - de Souza, William Marciel

AU - Romeiro, Marilia Farignoli

AU - Sabino-Santos, Gilberto

AU - Maia, Felipe Gonçalves Motta

AU - Fumagalli, Marcilio Jorge

AU - Modha, Sejal

AU - Nunes, Marcio Roberto Teixeira

AU - Murcia, Pablo Ramiro

AU - Figueiredo, Luiz Tadeu Moraes

PY - 2018/6

Y1 - 2018/6

N2 - The Hepeviridae comprise single-stranded positive-sense RNA viruses classified into two genera, Orthohepevirus and Piscihepevirus. Orthohepeviruses have a wide host range that includes rodents, but previous studies had been restricted to rodents of the Muridae family. In this study, we applied a high-throughput sequencing approach to examine the presence of orthohepeviruses in rodents from São Paulo State, Brazil. We also used RT-PCR to determine the frequency of orthohepeviruses in our sampled population. We identified novel orthohepeviruses in blood samples derived from Necromys lasiurus (1.19%) and Calomys tener (3.66%). Therefore, our results expand the host range and viral diversity of the Hepeviridae family.

AB - The Hepeviridae comprise single-stranded positive-sense RNA viruses classified into two genera, Orthohepevirus and Piscihepevirus. Orthohepeviruses have a wide host range that includes rodents, but previous studies had been restricted to rodents of the Muridae family. In this study, we applied a high-throughput sequencing approach to examine the presence of orthohepeviruses in rodents from São Paulo State, Brazil. We also used RT-PCR to determine the frequency of orthohepeviruses in our sampled population. We identified novel orthohepeviruses in blood samples derived from Necromys lasiurus (1.19%) and Calomys tener (3.66%). Therefore, our results expand the host range and viral diversity of the Hepeviridae family.

KW - Hepatitis E virus

KW - Hepeviridae

KW - Orthohepevirus

KW - Rodent-borne viruses

KW - Viral hepatitis

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U2 - 10.1016/j.virol.2018.03.025

DO - 10.1016/j.virol.2018.03.025

M3 - Article

C2 - 29627586

AN - SCOPUS:85044968715

SN - 0042-6822

VL - 519

SP - 12

EP - 16

JO - Virology

JF - Virology

ER -

Novel orthohepeviruses in wild rodents from São Paulo State, Brazil

Abstract

Keywords

ASJC Scopus subject areas

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