Novel mechanisms of central nervous system damage in HIV infection

Joy E. Hazleton, Joan W. Berman, Eliseo A. Eugenin

Research output: Contribution to journalReview articlepeer-review

41 Scopus citations


Human immunodeficiency virus-1 infection of the central nervous system is an early event after primary infection, resulting in motor and cognitive defects in a significant number of individuals despite successful antiretroviral therapy. The pathology of the infected brain is characterized by enhanced leukocyte infiltration, microglial activation and nodules, aberrant expression of inflammatory factors, neuronal dysregulation and loss, and blood-brain barrier disruption. Months to years following the primary infection, these central nervous system insults result in a spectrum of motor and cognitive dysfunction, ranging from mild impairment to frank dementia. The mechanisms that mediate impairment are still not fully defined. In this review we discuss the cellular and molecular mechanisms that facilitate impairment and new data that implicate intercellular communication systems, gap junctions and tunneling nanotubes, as mediators of human immunodeficiency virus-1 toxicity and infection within the central nervous system. These data suggest potential targets for novel therapeutics.

Original languageEnglish (US)
Pages (from-to)39-49
Number of pages11
JournalHIV/AIDS - Research and Palliative Care
StatePublished - 2010
Externally publishedYes


  • Aids
  • Chemokines
  • Dementia
  • Gap junctions
  • Inflammation
  • Nanotubes

ASJC Scopus subject areas

  • Infectious Diseases
  • Health Policy
  • Dermatology
  • Epidemiology
  • Virology


Dive into the research topics of 'Novel mechanisms of central nervous system damage in HIV infection'. Together they form a unique fingerprint.

Cite this