Novel dihydroisoxazoline-alkyl carbon chain hybrid artemisinin analogues (artemalogs): Synthesis and antitumor activities

Gang Liu; Shanshan Song; Xiaohua Liu; Ao Zhang; Zehong Miao; Chunyong Ding

doi:10.1039/c6ra17323c

Novel dihydroisoxazoline-alkyl carbon chain hybrid artemisinin analogues (artemalogs): Synthesis and antitumor activities

Gang Liu, Shanshan Song, Xiaohua Liu, Ao Zhang, Zehong Miao, Chunyong Ding

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Two new series of dihydroisoxazoline-alkyl carbon chain hybrid artemisinin analogues (artemalogs) were designed and synthesized though a 1,3-dipolar cycloaddition. Subsequent pharmacological screening led to several compounds having dramatically improved antiproliferative effects against several human tumor cell lines compared to artemisinin and dihydroartemisinin. Mechanistic studies on the most potent artemalogs were investigated.

Original language	English (US)
Pages (from-to)	98975-98984
Number of pages	10
Journal	RSC Advances
Volume	6
Issue number	101
DOIs	https://doi.org/10.1039/c6ra17323c
State	Published - 2016
Externally published	Yes

ASJC Scopus subject areas

General Chemistry
General Chemical Engineering

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10.1039/c6ra17323c

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abstract = "Two new series of dihydroisoxazoline-alkyl carbon chain hybrid artemisinin analogues (artemalogs) were designed and synthesized though a 1,3-dipolar cycloaddition. Subsequent pharmacological screening led to several compounds having dramatically improved antiproliferative effects against several human tumor cell lines compared to artemisinin and dihydroartemisinin. Mechanistic studies on the most potent artemalogs were investigated.",

author = "Gang Liu and Shanshan Song and Xiaohua Liu and Ao Zhang and Zehong Miao and Chunyong Ding",

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T1 - Novel dihydroisoxazoline-alkyl carbon chain hybrid artemisinin analogues (artemalogs)

T2 - Synthesis and antitumor activities

AU - Liu, Gang

AU - Song, Shanshan

AU - Liu, Xiaohua

AU - Zhang, Ao

AU - Miao, Zehong

AU - Ding, Chunyong

N1 - Publisher Copyright: © The Royal Society of Chemistry 2016.

PY - 2016

Y1 - 2016

N2 - Two new series of dihydroisoxazoline-alkyl carbon chain hybrid artemisinin analogues (artemalogs) were designed and synthesized though a 1,3-dipolar cycloaddition. Subsequent pharmacological screening led to several compounds having dramatically improved antiproliferative effects against several human tumor cell lines compared to artemisinin and dihydroartemisinin. Mechanistic studies on the most potent artemalogs were investigated.

AB - Two new series of dihydroisoxazoline-alkyl carbon chain hybrid artemisinin analogues (artemalogs) were designed and synthesized though a 1,3-dipolar cycloaddition. Subsequent pharmacological screening led to several compounds having dramatically improved antiproliferative effects against several human tumor cell lines compared to artemisinin and dihydroartemisinin. Mechanistic studies on the most potent artemalogs were investigated.

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Novel dihydroisoxazoline-alkyl carbon chain hybrid artemisinin analogues (artemalogs): Synthesis and antitumor activities

Abstract

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