TY - JOUR
T1 - Not So EASE-Y
T2 - How Often do Hospitalized Infective Endocarditis Patients Meet Criteria for Early Surgery?
AU - Amin Kashef, Mohammad
AU - Atreya, Auras R.
AU - Hernandez-Montfort, Jaime
AU - Frideric, Jennifer
AU - Lagu, Tara
PY - 2016/1/1
Y1 - 2016/1/1
N2 - Infective endocarditis (IE) has historically caused significant morbidity and mortality. Valve surgery reduces systemic embolization and mortality, but the optimal timing is controversial. The EASE (Early Surgery Versus Conventional Treatment for Infective Endocarditis) trial, which employed strict inclusion and exclusion criteria, showed that early surgery could reduce the risk of embolic events for a subset of patients. The aim of the present study was to determine the proportion of adult IE patients seen in usual clinical practice at a single tertiary medical center that would meet EASE enrollment criteria. Over a four-year period, only 10 of 88 patients (11.3%) were found to meet EASE enrollment criteria. These results have important research implications, and highlight the differences between populations of patients used in clinical trials and patients seen in practice.
AB - Infective endocarditis (IE) has historically caused significant morbidity and mortality. Valve surgery reduces systemic embolization and mortality, but the optimal timing is controversial. The EASE (Early Surgery Versus Conventional Treatment for Infective Endocarditis) trial, which employed strict inclusion and exclusion criteria, showed that early surgery could reduce the risk of embolic events for a subset of patients. The aim of the present study was to determine the proportion of adult IE patients seen in usual clinical practice at a single tertiary medical center that would meet EASE enrollment criteria. Over a four-year period, only 10 of 88 patients (11.3%) were found to meet EASE enrollment criteria. These results have important research implications, and highlight the differences between populations of patients used in clinical trials and patients seen in practice.
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M3 - Article
C2 - 27989088
AN - SCOPUS:85045114949
SN - 0966-8519
VL - 25
SP - 72
EP - 74
JO - The Journal of heart valve disease
JF - The Journal of heart valve disease
IS - 1
ER -