Abstract
Regulatory T cells (Tregs) blunt uncontrolled immune responses. In advanced human immunodeficiency virus (HIV) infection, the total number of Tregs is decreased, but the proportion of T cells with a regulatory phenotype is highly variable. We studied CD4+CD25+FoxP3+ T cells from patients successfully treated with combination antiretroviral therapy (ART). The proportion of CD4+CD25+FoxP3+ cells transiently increased and then decreased from a median of 13% at baseline to 5.1% at 48 weeks, similar to values in normal subjects. These data suggest that with effective therapy, the regulatory cell numbers normalize, and that the inflammatory signals driving their production may also abate.
Original language | English (US) |
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Pages (from-to) | 496-499 |
Number of pages | 4 |
Journal | Journal of Infectious Diseases |
Volume | 203 |
Issue number | 4 |
DOIs | |
State | Published - Feb 15 2011 |
ASJC Scopus subject areas
- General Medicine