Noninvasive monitoring of glucose concentration with optical coherence tomography

Rinat O. Esenaliev; Krill V. Larin; Irina V. Larina; Massoud Motamedi

doi:10.1364/OL.26.000992

Noninvasive monitoring of glucose concentration with optical coherence tomography

Rinat O. Esenaliev, Krill V. Larin, Irina V. Larina, Massoud Motamedi

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Abstract

We have proposed a tested in tissue phantoms and in vivo a novel sensor based on optical coherence tomography (OCT) for noninvasive and continuous monitoring of blood glucose concentration. OCT images were obtained from pig and rabbit skin before and after glucose administration. Slopes of OCT signals decreased substantially (∼40% in tissues in vivo) and linearly with the increase of blood glucose concentration from 4 to 30 mM, typical for normal and diabetic subjects. Phantom studies demonstrated 1% accuracy of scattering-coefficient measurement. Our theoretical and experimental studies suggest that glucose concentration can potentially be measured noninvasively with high sensitivity and accuracy with OCT systems.

Original language	English (US)
Pages (from-to)	992-994
Number of pages	3
Journal	Optics Letters
Volume	26
Issue number	13
DOIs	https://doi.org/10.1364/OL.26.000992
State	Published - Jul 1 2001

ASJC Scopus subject areas

Atomic and Molecular Physics, and Optics

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Noninvasive monitoring of glucose concentration with optical coherence tomography

Abstract

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