Abstract
This article discusses the difficulty of differentiating three causes of adult androgen excess including nonclassic congenital adrenal hyperplasia caused by 21-hydroxylase deficiency, polycystic ovarian syndrome and heterozygote carrier of CYP21 mutations based on clinical findings. It also reviews the screening modalities that discriminate patients with nonclassic congenital adrenal hyperplasia and the heterozygote carrier of CYP21 mutations from the normal population. In addition, the current management of hyperandrogenism and ovulatory dysfunction in these patients is described.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 239-246 |
| Number of pages | 8 |
| Journal | Expert Review of Endocrinology and Metabolism |
| Volume | 8 |
| Issue number | 3 |
| DOIs | |
| State | Published - May 2013 |
Keywords
- 21-hydroxylase deficiency
- diagnosis
- heterozygote carrier
- hyperandrogenism
- nonclassic congenital adrenal hyperplasia
- treatment
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism