TY - JOUR
T1 - Nocturnal urinary excretion of 6-hydroxymelatonin sulfate in prepubertal major depressive disorder
AU - Waterman, G. Scott
AU - Ryan, Neal D.
AU - Perel, James M.
AU - Dahl, Ronald E.
AU - Birmaher, Boris
AU - Williamson, Douglas E.
AU - Thomas, Christopher R.
AU - Puig-Antich, Joaquim
PY - 1992/3/15
Y1 - 1992/3/15
N2 - Levels of the melatonin metabolite, 6-hydroxymelatonin sulfate, were measured in overnight urine from 31 prepubertal children with major depressive disorder and 15 normal control children with very low family loading for affective disorder. The two groups did not differ with regard to their nocturnal excretion of this compound, nor was depressive subgroup identified whose 6-hydroxymelatonin sulfate excretion differed from that of the control group. Previous studies of pineal function in depression are reviewed and discussed in the context of the present investigation.
AB - Levels of the melatonin metabolite, 6-hydroxymelatonin sulfate, were measured in overnight urine from 31 prepubertal children with major depressive disorder and 15 normal control children with very low family loading for affective disorder. The two groups did not differ with regard to their nocturnal excretion of this compound, nor was depressive subgroup identified whose 6-hydroxymelatonin sulfate excretion differed from that of the control group. Previous studies of pineal function in depression are reviewed and discussed in the context of the present investigation.
UR - http://www.scopus.com/inward/record.url?scp=0026590934&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026590934&partnerID=8YFLogxK
U2 - 10.1016/0006-3223(92)90244-T
DO - 10.1016/0006-3223(92)90244-T
M3 - Article
C2 - 1581437
AN - SCOPUS:0026590934
SN - 0006-3223
VL - 31
SP - 582
EP - 590
JO - Biological Psychiatry
JF - Biological Psychiatry
IS - 6
ER -