No strong association among epigenetic modifications by DNA methylation, telomere length, and physical fitness in biological aging

Yasuhiro Seki; Dora Aczel; Ferenc Torma; Matyas Jokai; Anita Boros; Katsuhiko Suzuki; Mitsuru Higuchi; Kumpei Tanisawa; Istvan Boldogh; Steve Horvath; Zsolt Radak

doi:10.1007/s10522-022-10011-0

No strong association among epigenetic modifications by DNA methylation, telomere length, and physical fitness in biological aging

Yasuhiro Seki, Dora Aczel, Ferenc Torma, Matyas Jokai, Anita Boros, Katsuhiko Suzuki, Mitsuru Higuchi, Kumpei Tanisawa, Istvan Boldogh, Steve Horvath, Zsolt Radak

Research output: Contribution to journal › Article › peer-review

Abstract

Cellular senescence is greatly accelerated by telomere shortening, and the steps forward in human aging are strongly influenced by environmental and lifestyle factors, whether DNA methylation (DNAm) is affected by exercise training, remains unclear. In the present study, we investigated the relationships between physiological functions, maximal oxygen uptake (VO2max), vertical jump, working memory, telomere length (TL) assessed by RT-PCR, DNA methylation-based estimation of TL (DNAmTL), and DNA methylation-based biomarkers of aging of master rowers (N = 146) and sedentary subjects (N = 95), aged between 37 and 85 years. It was found that the TL inversely correlated with chronological age. We could not detect an association between telomere length and VO2max, vertical jump, and working memory by RT-PCR method, while these physiological test results showed a correlation with DNAmTL. DNAmGrimAge and DNAmPhenoAge acceleration were inversely associated with telomere length assessed by both methods. It appears that there are no strong beneficial effects of exercise or physiological fitness on telomere shortening, however, the degree of DNA methylation is associated with telomere length.

Original language	English (US)
Pages (from-to)	245-255
Number of pages	11
Journal	Biogerontology
Volume	24
Issue number	2
DOIs	https://doi.org/10.1007/s10522-022-10011-0
State	Published - Apr 2023
Externally published	Yes

Keywords

DNA methylation
Epigenetical aging
Exercise
Physical fitness
Telomere

ASJC Scopus subject areas

Aging
Gerontology
Geriatrics and Gerontology

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10.1007/s10522-022-10011-0

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title = "No strong association among epigenetic modifications by DNA methylation, telomere length, and physical fitness in biological aging",

abstract = "Cellular senescence is greatly accelerated by telomere shortening, and the steps forward in human aging are strongly influenced by environmental and lifestyle factors, whether DNA methylation (DNAm) is affected by exercise training, remains unclear. In the present study, we investigated the relationships between physiological functions, maximal oxygen uptake (VO2max), vertical jump, working memory, telomere length (TL) assessed by RT-PCR, DNA methylation-based estimation of TL (DNAmTL), and DNA methylation-based biomarkers of aging of master rowers (N = 146) and sedentary subjects (N = 95), aged between 37 and 85 years. It was found that the TL inversely correlated with chronological age. We could not detect an association between telomere length and VO2max, vertical jump, and working memory by RT-PCR method, while these physiological test results showed a correlation with DNAmTL. DNAmGrimAge and DNAmPhenoAge acceleration were inversely associated with telomere length assessed by both methods. It appears that there are no strong beneficial effects of exercise or physiological fitness on telomere shortening, however, the degree of DNA methylation is associated with telomere length.",

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doi = "10.1007/s10522-022-10011-0",

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T1 - No strong association among epigenetic modifications by DNA methylation, telomere length, and physical fitness in biological aging

AU - Seki, Yasuhiro

AU - Aczel, Dora

AU - Torma, Ferenc

AU - Jokai, Matyas

AU - Boros, Anita

AU - Suzuki, Katsuhiko

AU - Higuchi, Mitsuru

AU - Tanisawa, Kumpei

AU - Boldogh, Istvan

AU - Horvath, Steve

AU - Radak, Zsolt

PY - 2023/4

Y1 - 2023/4

N2 - Cellular senescence is greatly accelerated by telomere shortening, and the steps forward in human aging are strongly influenced by environmental and lifestyle factors, whether DNA methylation (DNAm) is affected by exercise training, remains unclear. In the present study, we investigated the relationships between physiological functions, maximal oxygen uptake (VO2max), vertical jump, working memory, telomere length (TL) assessed by RT-PCR, DNA methylation-based estimation of TL (DNAmTL), and DNA methylation-based biomarkers of aging of master rowers (N = 146) and sedentary subjects (N = 95), aged between 37 and 85 years. It was found that the TL inversely correlated with chronological age. We could not detect an association between telomere length and VO2max, vertical jump, and working memory by RT-PCR method, while these physiological test results showed a correlation with DNAmTL. DNAmGrimAge and DNAmPhenoAge acceleration were inversely associated with telomere length assessed by both methods. It appears that there are no strong beneficial effects of exercise or physiological fitness on telomere shortening, however, the degree of DNA methylation is associated with telomere length.

AB - Cellular senescence is greatly accelerated by telomere shortening, and the steps forward in human aging are strongly influenced by environmental and lifestyle factors, whether DNA methylation (DNAm) is affected by exercise training, remains unclear. In the present study, we investigated the relationships between physiological functions, maximal oxygen uptake (VO2max), vertical jump, working memory, telomere length (TL) assessed by RT-PCR, DNA methylation-based estimation of TL (DNAmTL), and DNA methylation-based biomarkers of aging of master rowers (N = 146) and sedentary subjects (N = 95), aged between 37 and 85 years. It was found that the TL inversely correlated with chronological age. We could not detect an association between telomere length and VO2max, vertical jump, and working memory by RT-PCR method, while these physiological test results showed a correlation with DNAmTL. DNAmGrimAge and DNAmPhenoAge acceleration were inversely associated with telomere length assessed by both methods. It appears that there are no strong beneficial effects of exercise or physiological fitness on telomere shortening, however, the degree of DNA methylation is associated with telomere length.

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KW - Epigenetical aging

KW - Exercise

KW - Physical fitness

KW - Telomere

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No strong association among epigenetic modifications by DNA methylation, telomere length, and physical fitness in biological aging

Abstract

Keywords

ASJC Scopus subject areas

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