Nipah virus-associated encephalitis outbreak, Siliguri, India

Mandeep S. Chadha; James A. Comer; Luis Lowe; Paul A. Rota; Pierre E. Rollin; William J. Bellini; Thomas G. Ksiazek; Akhilesh C. Mishra

doi:10.3201/eid1202.051247

Nipah virus-associated encephalitis outbreak, Siliguri, India

Mandeep S. Chadha, James A. Comer, Luis Lowe, Paul A. Rota, Pierre E. Rollin, William J. Bellini, Thomas G. Ksiazek, Akhilesh C. Mishra

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325 Scopus citations

Abstract

During January and February 2001, an outbreak of febrile illness associated with altered sensorium was observed in Siliguri, West Bengal, India. Laboratory investigations at the time of the outbreak did not identify an infectious agent. Because Siliguri is in close proximity to Bangladesh, where outbreaks of Nipah virus (NiV) infection were recently described, clinical material obtained during the Siliguri outbreak was retrospectively analyzed for evidence of NiV infection. NiV-specific immunoglobulin M (IgM) and IgG antibodies were detected in 9 of 18 patients. Reverse transcription-polymerase chain reaction (RTPCR) assays detected RNA from NiV in urine samples from 5 patients. Sequence analysis confirmed that the PCR products were derived from NiV RNA and suggested that the NiV from Siliguri was more closely related to NiV isolates from Bangladesh than to NiV isolates from Malaysia. NiV infection has not been previously detected in India.

Original language	English (US)
Pages (from-to)	235-240
Number of pages	6
Journal	Emerging infectious diseases
Volume	12
Issue number	2
DOIs	https://doi.org/10.3201/eid1202.051247
State	Published - Feb 2006
Externally published	Yes

ASJC Scopus subject areas

Epidemiology
Microbiology (medical)
Infectious Diseases

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title = "Nipah virus-associated encephalitis outbreak, Siliguri, India",

abstract = "During January and February 2001, an outbreak of febrile illness associated with altered sensorium was observed in Siliguri, West Bengal, India. Laboratory investigations at the time of the outbreak did not identify an infectious agent. Because Siliguri is in close proximity to Bangladesh, where outbreaks of Nipah virus (NiV) infection were recently described, clinical material obtained during the Siliguri outbreak was retrospectively analyzed for evidence of NiV infection. NiV-specific immunoglobulin M (IgM) and IgG antibodies were detected in 9 of 18 patients. Reverse transcription-polymerase chain reaction (RTPCR) assays detected RNA from NiV in urine samples from 5 patients. Sequence analysis confirmed that the PCR products were derived from NiV RNA and suggested that the NiV from Siliguri was more closely related to NiV isolates from Bangladesh than to NiV isolates from Malaysia. NiV infection has not been previously detected in India.",

author = "Chadha, {Mandeep S.} and Comer, {James A.} and Luis Lowe and Rota, {Paul A.} and Rollin, {Pierre E.} and Bellini, {William J.} and Ksiazek, {Thomas G.} and Mishra, {Akhilesh C.}",

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AU - Chadha, Mandeep S.

AU - Comer, James A.

AU - Lowe, Luis

AU - Rota, Paul A.

AU - Rollin, Pierre E.

AU - Bellini, William J.

AU - Ksiazek, Thomas G.

AU - Mishra, Akhilesh C.

PY - 2006/2

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Nipah virus-associated encephalitis outbreak, Siliguri, India

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