NGF levels decrease in the spinal cord and dorsal root ganglion after spinal hemisection

Adrianne D. Bennett; Giulio Taglialatela; Regino Perez-Polo; Claire E. Hulsebosch

doi:10.1097/00001756-199903170-00040

NGF levels decrease in the spinal cord and dorsal root ganglion after spinal hemisection

Adrianne D. Bennett, Giulio Taglialatela, Regino Perez-Polo, Claire E. Hulsebosch

Neurology

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

To examine changes in nerve growth factor (NGF) levels in spinal cord and dorsal root ganglia (DRG) after spinal injury, male Sprague-Dawley rats weighing 150-175 g were given spinal hemisections. NGF content was measured at various post-surgical times and compared with naive controls (n=4 per time point) in the spinal cord, DRG and blood serum by ELISA techniques (Promega). Levels of NGF in the blood serum were significantly increased 8-fold at 48 h but were significantly decreased in the spinal cord and DRG by 2- to 4-fold until 7 days postsurgery (ANOVA, p<0.05). Contrary to accepted dogma, spinal injury results in decreased levels of NGF in the spinal cord and DRG following spinal injury.

Original language	English (US)
Pages (from-to)	889-893
Number of pages	5
Journal	NeuroReport
Volume	10
Issue number	4
DOIs	https://doi.org/10.1097/00001756-199903170-00040
State	Published - Mar 17 1999

Keywords

Dorsal root ganglia
NGF
Nerve growth factor
Neurotrophin
Neurotropin
Rat, Spinal cord injury

ASJC Scopus subject areas

General Neuroscience

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10.1097/00001756-199903170-00040

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abstract = "To examine changes in nerve growth factor (NGF) levels in spinal cord and dorsal root ganglia (DRG) after spinal injury, male Sprague-Dawley rats weighing 150-175 g were given spinal hemisections. NGF content was measured at various post-surgical times and compared with naive controls (n=4 per time point) in the spinal cord, DRG and blood serum by ELISA techniques (Promega). Levels of NGF in the blood serum were significantly increased 8-fold at 48 h but were significantly decreased in the spinal cord and DRG by 2- to 4-fold until 7 days postsurgery (ANOVA, p<0.05). Contrary to accepted dogma, spinal injury results in decreased levels of NGF in the spinal cord and DRG following spinal injury.",

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N2 - To examine changes in nerve growth factor (NGF) levels in spinal cord and dorsal root ganglia (DRG) after spinal injury, male Sprague-Dawley rats weighing 150-175 g were given spinal hemisections. NGF content was measured at various post-surgical times and compared with naive controls (n=4 per time point) in the spinal cord, DRG and blood serum by ELISA techniques (Promega). Levels of NGF in the blood serum were significantly increased 8-fold at 48 h but were significantly decreased in the spinal cord and DRG by 2- to 4-fold until 7 days postsurgery (ANOVA, p<0.05). Contrary to accepted dogma, spinal injury results in decreased levels of NGF in the spinal cord and DRG following spinal injury.

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NGF levels decrease in the spinal cord and dorsal root ganglion after spinal hemisection

Abstract

Keywords

ASJC Scopus subject areas

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