New insights into the pathobiology of portal hypertension

Praveen Guturu, Vijay Shah

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Portal Hypertension is a frequent complication of cirrhosis and causes significant morbidity and mortality. Increased intrahepatic resistance is the primary factor but portal hypertension is also associated with changes in systemic and porto-sytemic collateral circulation. Cirrhosis is a state of vasoregulatory imbalance with excess vasoconstrictors and less vasodilators in hepatic circulation and the reverse is true for systemic circulation. Multiple pathophysiologic mechanisms including endothelial dysfunction, sinusoidal remodeling and angiogenesis are involved in increasing resistance in hepatic vascular bed. Current evidence suggests that these changes in vasoreactivity contribute to a significant proportion of intrahepatic vascular resistance and that they are reversible, providing an attractive target for therapeutic intervention.

Original languageEnglish (US)
Pages (from-to)1016-1019
Number of pages4
JournalHepatology Research
Issue number10
StatePublished - 2009
Externally publishedYes


  • Endothelial dysfunction
  • Hepatic stellate cells
  • Pathobiology
  • Portal hypertension
  • Sinusoidal remodeling

ASJC Scopus subject areas

  • Hepatology
  • Infectious Diseases


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