Neutralizing antibody response elicited by SARS-CoV-2 receptor-binding domain

Ping Han Huang, Hsiao Han Tsai, Bo Hung Liao, Yi Ling Lin, Jia Tsrong Jan, Mi Hua Tao, Yu Chi Chou, Che Ming Jack Hu, Hui Wen Chen

Research output: Contribution to journalComment/debatepeer-review


A safe and effective vaccine candidate is urgently needed for the ongoing COVID-19 pandemic, caused by SARS-CoV-2. Here we report that recombinant SARS-CoV-2 RBD protein immunization in mice is able to elicit a strong antibody response and potent neutralizing capability as measured using live or pseudotyped SARS-CoV-2 neutralization assays.

Original languageEnglish (US)
Pages (from-to)654-655
Number of pages2
JournalHuman Vaccines and Immunotherapeutics
Issue number3
StatePublished - 2021
Externally publishedYes


  • SARS-CoV-2
  • neutralizing antibodies
  • receptor-binding domain
  • vaccine

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pharmacology


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