Neuroprotective effect of σ₁-receptor ligand 4-phenyl-1-(4-phenylbutyl) piperidine (PPBP) is linked to reduced neuronal nitric oxide production

Keyphrases

• Neuroprotective Effect 100%
• Ligand-receptor Binding 100%
• Nitric Oxide Production 100%
• Piperidine 100%
• A1 Receptor 100%
• Phenyl 100%
• Neuronal Nitric Oxide 100%
• Neuronal Nitric Oxide Synthase (nNOS) 45%
• Infarction Volume 36%
• Transient Middle Cerebral Artery Occlusion (tMCAO) 27%
• 7-nitroindazole 27%
• Ischemia 18%
• Reperfusion 18%
• Striatum 18%
• Striatal 18%
• Occlusion 18%
• Attenuation 9%
• Neuroprotection 9%
• Microdialysis 9%
• Tissue Damage 9%
• Neurotoxicity 9%
• Histology 9%
• Wild Mice 9%
• Combination Therapy 9%
• Ischemic Brain 9%
• Non-ischemic 9%
• Nitric Oxide Synthase Inhibitors 9%
• Adult Male 9%
• Arginine 9%
• Nitric Oxide Synthase Activity 9%
• Wild Strain 9%
• Citrulline 9%
• Ischemic Insult 9%
• Wistar Rats 9%
• Cerebral Cortex 9%
• Halothane 9%
• Early Reperfusion 9%
• 2,3,5-triphenyltetrazolium Chloride 9%
• Experimental Stroke 9%
• Physiological Variables 9%
• Null mutant 9%
• Intraluminal Filament 9%
• Mechanisms of Neuroprotection 9%
• Selective Neuronal Nitric Oxide Synthase Inhibitors 9%

INIS

• production 100%
• receptors 100%
• nitric oxide 100%
• ligands 100%
• piperidines 100%
• ischemia 41%
• volume 33%
• cerebral arteries 25%
• mice 16%
• in vivo 16%
• brain 16%
• hypothesis 8%
• rats 8%
• data 8%
• tissues 8%
• recovery 8%
• attenuation 8%
• damage 8%
• adults 8%
• strains 8%
• reduction 8%
• mutants 8%
• inhibition 8%
• histology 8%
• males 8%
• infusion 8%
• combined therapy 8%
• arginine 8%
• chlorides 8%
• filaments 8%
• citrulline 8%
• cerebral cortex 8%

Neuroscience

• Nitric Oxide 100%
• Neuroprotective Agent 100%
• Eicosanoid Receptor 100%
• Piperidine 100%
• Neuronal Nitric Oxide Synthase 54%
• Infarction 36%
• Middle Cerebral Artery 27%
• 7-Nitroindazole 27%
• Brain 18%
• Neuroprotection 18%
• In Vivo 18%
• Ischemia 18%
• Striatum 18%
• Microdialysis 9%
• Neurotoxicity 9%
• Stroke 9%
• Arginine 9%
• Cerebral Cortex 9%
• Histology 9%
• Halothane 9%
• Citrulline 9%
• Chloride 9%