Abstract
The presently available data about stress and its effects is too broad. That's why this paper will focus on the effect of stress hormones in some brain areas, like limbic structures and the hypothalamo-pituitary-adrenal axis. In this way we will discuss how repetitive stress can change those areas, mainly by the effect on its two types of nuclear receptors, changing the basal activity of the amygdala, hippocampus and the medial prefrontal cortex, resulting in an increased hypothalamo-pituitary-adrenal axis function and impairing cognitive functions like memory. However, the exact mechanism by which these effects are produced is poorly understood. That is why one of the challenges for future research is to link the cellular changes with its behavioral effects in order to understand how it works in a living organism.
Translated title of the contribution | Neurobiology of acute and chronic stress: Their effect on the hypothalamo-pituitary-adrenal axis and memory |
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Original language | Spanish |
Pages (from-to) | 78-90 |
Number of pages | 13 |
Journal | Revista Ecuatoriana de Neurologia |
Volume | 21 |
Issue number | 1-3 |
State | Published - 2012 |
Externally published | Yes |
Keywords
- Chronic stress
- Glucocorticoids
- Hypothalamo-pituitary-adrenal axis
- Long-term synaptic potentiation
- Memory
ASJC Scopus subject areas
- Neurology
- Clinical Neurology