Neither microbial translocation nor TLR responsiveness are likely explanations for preexisting immune activation in women who subsequently acquired HIV in CAPRISA 004

Vivek Naranbhai; Natasha Samsunder; Netanya G. Sandler; Annalys Roque; Quarraisha Abdool Karim; Thumbi Ndung'U; William H. Carr; Marcus Altfeld; Daniel C. Douek; Salim S.Abdool Karim

doi:10.1097/QAI.0b013e31828e604b

Neither microbial translocation nor TLR responsiveness are likely explanations for preexisting immune activation in women who subsequently acquired HIV in CAPRISA 004

Vivek Naranbhai, Natasha Samsunder, Netanya G. Sandler, Annalys Roque, Quarraisha Abdool Karim, Thumbi Ndung'U, William H. Carr, Marcus Altfeld, Daniel C. Douek, Salim S.Abdool Karim

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Innate immune activation was a strong predictor of HIV acquisition in women at risk for HIV in CAPRISA 004. Identifying the cause(s) of activation could enable targeted prevention interventions. In this study, plasma concentrations of lipopolysaccharide, soluble CD14, and intestinal fatty acid-binding protein did not differ between subjects who did or did not subsequently acquire HIV nor were these levels correlated with plasma cytokines or natural killer cell activation. There was no difference between HIV acquirers and non-acquirers in the chemokine and cytokine responses of peripheral blood mononuclear cells stimulated with TLR2, 4, or 7/8 agonists. Further studies are required.

Original language	English (US)
Pages (from-to)	294-298
Number of pages	5
Journal	Journal of Acquired Immune Deficiency Syndromes
Volume	63
Issue number	3
DOIs	https://doi.org/10.1097/QAI.0b013e31828e604b
State	Published - Jul 1 2013
Externally published	Yes

Keywords

HIV
I-FABP
Immune activation
LPS
Microbial translocation
SCD14
TLR2
TLR4
TLR7/8

ASJC Scopus subject areas

Infectious Diseases
Pharmacology (medical)

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10.1097/QAI.0b013e31828e604b

Cite this

Naranbhai, V., Samsunder, N., Sandler, N. G., Roque, A., Karim, Q. A., Ndung'U, T., Carr, W. H., Altfeld, M., Douek, D. C., & Karim, S. S. A. (2013). Neither microbial translocation nor TLR responsiveness are likely explanations for preexisting immune activation in women who subsequently acquired HIV in CAPRISA 004. Journal of Acquired Immune Deficiency Syndromes, 63(3), 294-298. https://doi.org/10.1097/QAI.0b013e31828e604b

Neither microbial translocation nor TLR responsiveness are likely explanations for preexisting immune activation in women who subsequently acquired HIV in CAPRISA 004. / Naranbhai, Vivek; Samsunder, Natasha; Sandler, Netanya G. et al.
In: Journal of Acquired Immune Deficiency Syndromes, Vol. 63, No. 3, 01.07.2013, p. 294-298.

Research output: Contribution to journal › Article › peer-review

Naranbhai, V, Samsunder, N, Sandler, NG, Roque, A, Karim, QA, Ndung'U, T, Carr, WH, Altfeld, M, Douek, DC & Karim, SSA 2013, 'Neither microbial translocation nor TLR responsiveness are likely explanations for preexisting immune activation in women who subsequently acquired HIV in CAPRISA 004', Journal of Acquired Immune Deficiency Syndromes, vol. 63, no. 3, pp. 294-298. https://doi.org/10.1097/QAI.0b013e31828e604b

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abstract = "Innate immune activation was a strong predictor of HIV acquisition in women at risk for HIV in CAPRISA 004. Identifying the cause(s) of activation could enable targeted prevention interventions. In this study, plasma concentrations of lipopolysaccharide, soluble CD14, and intestinal fatty acid-binding protein did not differ between subjects who did or did not subsequently acquire HIV nor were these levels correlated with plasma cytokines or natural killer cell activation. There was no difference between HIV acquirers and non-acquirers in the chemokine and cytokine responses of peripheral blood mononuclear cells stimulated with TLR2, 4, or 7/8 agonists. Further studies are required.",

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Neither microbial translocation nor TLR responsiveness are likely explanations for preexisting immune activation in women who subsequently acquired HIV in CAPRISA 004

Abstract

Keywords

ASJC Scopus subject areas

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