NCCN task force report: Management of patients with Gastrointestinal Stromal Tumor (GIST) - Update of the NCCN clinical practice guidelines

George D. Demetri, Robert S. Benjamin, Charles D. Blanke, Jean Yves Blay, Paolo Casali, Haesun Choi, Christopher L. Corless, Maria Debiec-Rychter, Ronald P. DeMatteo, David S. Ettinger, George A. Fisher, Christopher D.M. Fletcher, Alessandro Gronchi, Peter Hohenberger, Miranda Hughes, Heikki Joensuu, Ian Judson, Axel Le Cesne, Robert G. Maki, Michael MorseAlberto S. Pappo, Peter W.T. Pisters, Chandrajit P. Raut, Peter Reichardt, Douglas S. Tyler, Annick D. Van Den Abbeele, Margaret Von Mehren, Jeffrey D. Wayne, John Zalcberg

Research output: Contribution to journalReview articlepeer-review

468 Scopus citations


The NCCN Soft Tissue Sarcoma Guidelines include a subsection about treatment recommendations for gastrointestinal stromal tumors (GISTs). The standard of practice rapidly changed after the introduction of effective molecularly targeted therapy (such as imatinib and sunitinib) for GIST. Because of these changes, NCCN organized a multidisciplinary panel composed of experts in the fields of medical oncology, molecular diagnostics, pathology, radiation oncology, and surgery to discuss the optimal approach for the care of patients with GIST at all stages of the disease. The GIST Task Force is composed of NCCN faculty and other key experts from the United States, Europe, and Australia. The Task Force met for the first time in October 2003 and again in December 2006 with the purpose of expanding on the existing NCCN guidelines for gastrointestinal sarcomas and identifying areas of future research to optimize our understanding and treatment of GIST.

Original languageEnglish (US)
Pages (from-to)S-1-S-29
JournalJNCCN Journal of the National Comprehensive Cancer Network
Issue numberSUPPL. 2
StatePublished - 2007
Externally publishedYes


  • Abdominal tumor
  • CD117
  • GIST
  • Gastric mass
  • Gastrointestinal stromal tumor
  • Gastrointestinal tract
  • Imatinib
  • KIT
  • Liver metastasis
  • NCCN Clinical Practice Guidelines
  • Sarcoma
  • Small bowel tumor
  • Stomach cancer
  • Sunitinib
  • Tyrosine kinase

ASJC Scopus subject areas

  • Oncology


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