Abstract
We investigated nasopharyngeal microbial community structure in COVID-19-positive and -negative patients. High-throughput 16S ribosomal RNA gene amplicon sequencing revealed significant microbial community structure differences between COVID-19-positive and -negative patients. This proof-of-concept study demonstrates that: (1) nasopharyngeal microbiome communities can be assessed using collection samples already collected for SARS-CoV-2 testing (viral transport media) and (2) SARS-CoV-2 infection is associated with altered dysbiotic microbial profiles which could be a biomarker for disease progression and prognosis in SARS-CoV-2.
Original language | English (US) |
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Article number | 10 |
Journal | Biological Procedures Online |
Volume | 23 |
Issue number | 1 |
DOIs | |
State | Published - Dec 2021 |
Externally published | Yes |
Keywords
- COVID-19
- Dysbiosis
- Microbiota
- Nasopharyngeal
- SARS-CoV-2
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology